Title:
METHOD FOR PREPARING CHOLIC ACID COMPOUND
Document Type and Number:
WIPO Patent Application WO/2019/085963
Kind Code:
A1
Abstract:
The present application belongs to the field of pharmaceutical chemistry, and relates to a method for preparing a cholic acid compound. Specifically, the present application provides a process for preparing a compound as shown in formula I, comprising subjecting a compound of formula 2 to an oxidization reaction to obtain a compound of formula 3; attaching a trimethylsilyl group to the compound of formula 3 to obtain a compound of formula 4; reacting the compound of formula 4 with acetaldehyde to obtain a compound of formula 5; subjecting the compound of formula 5 to a catalytic hydrogenation reaction to obtain a compound of formula 6; and converting a cyano group of the compound of formula 6 to a carboxyl group to give the compound of formula I. The preparation method has high yield, requires less purification operations, and is suitable for industrial application.
Inventors:
ZHANG XIQUAN (CN)
CHENG XINGDONG (CN)
ZHANG AIMING (CN)
XIA CHUNGUANG (CN)
CHEN LANG (CN)
GAO CE (CN)
CHENG XINGDONG (CN)
ZHANG AIMING (CN)
XIA CHUNGUANG (CN)
CHEN LANG (CN)
GAO CE (CN)
Application Number:
PCT/CN2018/113326
Publication Date:
May 09, 2019
Filing Date:
November 01, 2018
Export Citation:
Assignee:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN)
International Classes:
C07J9/00
Domestic Patent References:
| WO2016173524A1 | 2016-11-03 | |||
| WO2000037077A1 | 2000-06-29 | |||
| WO2016173524A1 | 2016-11-03 |
Foreign References:
| CN106661079A | 2017-05-10 |
Other References:
DJ. MANGELSDORF ET AL., CELL, vol. 83, 1995, pages 841 - 850
W. SEOL ET AL., MOL. ENDOCRINNOL, vol. 9, 1995, pages 72 - 85
D' AMORE ET AL.: "reports the following preparation route", J. MED. CHEM., vol. 57, 2014, pages 937 - 954
"Greene's Protective Groups in Organic Synthesis", WILEY PRESS, OR PROTECTING GROUPS PUBLISHED BY CHEMICAL INDUSTRY PRESS
See also references of EP 3705487A4
W. SEOL ET AL., MOL. ENDOCRINNOL, vol. 9, 1995, pages 72 - 85
D' AMORE ET AL.: "reports the following preparation route", J. MED. CHEM., vol. 57, 2014, pages 937 - 954
"Greene's Protective Groups in Organic Synthesis", WILEY PRESS, OR PROTECTING GROUPS PUBLISHED BY CHEMICAL INDUSTRY PRESS
See also references of EP 3705487A4
Attorney, Agent or Firm:
BEIJING SUNHOPE INTELLECTUAL PROPERTY LTD. (CN)
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