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Title:
METHOD FOR PREPARING COMPOSITION CONTAINING FACTOR 8 CAPABLE OF CONTROLLING CONTENT OF VON WILLEBRAND FACTOR (VWF) AND VON WILLEBRAND FACTOR
Document Type and Number:
WIPO Patent Application WO/2019/083319
Kind Code:
A3
Abstract:
The present invention relates to a method for preparing a composition containing factor 8 (FVIII) capable of controlling the content of von Willebrand factor (vWF) and von Willebrand factor (vWF) and, more specifically, to a method for preparing a composition containing factor 8 (FVIII) capable of controlling the content of von Willebrand factor (vWF) and von Willebrand factor (vWF) by separately purifying factor 8 (FVIII) and von Willebrand factor (vWF) from plasma in a single process and mixing factor 8 (FVIII) and von Willebrand factor (vWF) at a proper ratio. According to the present invention, a composition containing factor 8 (FVIII), which variously changes the content of von Willebrand factor (vWF), and von Willebrand factor (vWF) can be produced/purified without increasing the amount of impurities other than von Willebrand factor (vWF), compared with a single purified product of factor 8 (FVIII), without significantly increasing the processing time (within 3 hours) compared with a single purification process of factor 8 (FVIII), and without changing the yield of factor 8 (FVIII).

Inventors:
AHN JEE WON (KR)
KO KWAN YOUNG (KR)
YOON JEONG HYE (KR)
BAEK SEUNG-HO (KR)
KIM MIN JUNG (KR)
YEO GEUN HYE (KR)
LIM JEONG-AE (KR)
KIM SOO-KWANG (KR)
Application Number:
PCT/KR2018/012820
Publication Date:
June 20, 2019
Filing Date:
October 26, 2018
Export Citation:
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Assignee:
GREEN CROSS HOLDINGS CORP (KR)
International Classes:
C07K14/755; B01D15/36; C07K1/18
Domestic Patent References:
WO2015021423A22015-02-12
WO2016162310A12016-10-13
WO2010082184A12010-07-22
Foreign References:
EP0934748B12005-10-19
KR20100058520A2010-06-03
Other References:
See also references of EP 3719034A4
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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