Title:
METHOD FOR PREPARING COMPOUND OR BIOLOGICAL DRUG ENHANCING CNPASE ACTIVITY FOR TREATING HEART DISEASES
Document Type and Number:
WIPO Patent Application WO/2022/100720
Kind Code:
A1
Abstract:
A method for preparing a compound or a biological drug enhancing CNPase activity for treating heart diseases. The chemical method relates to using kaurane compounds to up-regulate the expression and activity of CNPase. Biological therapeutic drugs relate to the preparation of the CNPase enzyme expressed by using recombinant adeno-associated virus and local intervention therapy. In a rat myocardial hypertrophy and heart failure model, the method can effectively improve myocardial hypertrophy and myocardial remodeling, inhibit myocardial hypertrophy and fibrosis increase, and increase cardiac functions.
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Inventors:
WANG DONGFANG (CN)
CHEN KAIXIN (CN)
LU ZHIQIANG (CN)
TAN WEN (CN)
CHEN KAIXIN (CN)
LU ZHIQIANG (CN)
TAN WEN (CN)
Application Number:
PCT/CN2021/130496
Publication Date:
May 19, 2022
Filing Date:
November 14, 2021
Export Citation:
Assignee:
ZHUHAI YUANZHI HEALTH TECH CO LTD (CN)
International Classes:
A01K67/027; A61K31/19; A61P9/00; A61P9/04; A61P9/10; C12N15/864
Domestic Patent References:
| WO2005110383A1 | 2005-11-24 |
Foreign References:
| CN112472690A | 2021-03-12 | |||
| CN108348481A | 2018-07-31 |
Other References:
OLGA KRESTININA, YULIA BABURINA, VASSILIOS PAPADOPOULOS: "The Functions of Mitochondrial 2′,3′-Cyclic Nucleotide-3′-Phosphodiesterase and Prospects for Its Future", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 9, pages 1 - 18, XP055931722, DOI: 10.3390/ijms21093217
MEI YING, LIU BO, SU HAO, ZHANG HAO, LIU FEI, KE QINGJIN, SUN XIAOOU, TAN WEN: "Isosteviol sodium protects the cardiomyocyte response associated with the SIRT1/PGC‐1α pathway", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 24, no. 18, 1 September 2020 (2020-09-01), RO , pages 10866 - 10875, XP055931725, ISSN: 1582-1838, DOI: 10.1111/jcmm.15715
CHEN YAOXU, BENG HUIMIN, SU HAO, HAN FUPING, FAN ZHUO, LV NANYING, JOVANOVIĆ ALEKSANDAR, TAN WEN: "Isosteviol prevents the development of isoprenaline‑induced myocardial hypertrophy", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 44, no. 5, GR , pages 1932 - 1942, XP055931727, ISSN: 1107-3756, DOI: 10.3892/ijmm.2019.4342
CHEN, JIEDI: "The Protective Effects of Isosteviol Sodium on Myocardial Hypertrophy in Transverse Aortic Constriction Rats", CHINESE MASTER'S THESES FULL-TEXT DATABASE, MEDICINE&PUBLIC HEALTH, no. 12, 15 December 2015 (2015-12-15), pages 1 - 99, XP055931735
TAN K. S.: "CNPase, a 2',3'-Cyclic-nucleotide 3'-phosphodiesterase, as a Therapeutic Target to Attenuate Cardiac Hypertrophy by Enhancing Mitochondrial Energy Production", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, no. 19, 6 October 2021 (2021-10-06), pages 1 - 15, XP055931789
WANG DONGFANG; TAN KEAI SINN; ARIAS-MORENO XABIER; TAN WEN; CHENG GUOHUA: "Sirt3 increases CNPase enzymatic activity through deacetylation and facilitating substrate accessibility", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 571, 27 July 2021 (2021-07-27), Amsterdam NL , pages 181 - 187, XP086754306, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2021.07.079
MEI YING, LIU BO, SU HAO, ZHANG HAO, LIU FEI, KE QINGJIN, SUN XIAOOU, TAN WEN: "Isosteviol sodium protects the cardiomyocyte response associated with the SIRT1/PGC‐1α pathway", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 24, no. 18, 1 September 2020 (2020-09-01), RO , pages 10866 - 10875, XP055931725, ISSN: 1582-1838, DOI: 10.1111/jcmm.15715
CHEN YAOXU, BENG HUIMIN, SU HAO, HAN FUPING, FAN ZHUO, LV NANYING, JOVANOVIĆ ALEKSANDAR, TAN WEN: "Isosteviol prevents the development of isoprenaline‑induced myocardial hypertrophy", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 44, no. 5, GR , pages 1932 - 1942, XP055931727, ISSN: 1107-3756, DOI: 10.3892/ijmm.2019.4342
CHEN, JIEDI: "The Protective Effects of Isosteviol Sodium on Myocardial Hypertrophy in Transverse Aortic Constriction Rats", CHINESE MASTER'S THESES FULL-TEXT DATABASE, MEDICINE&PUBLIC HEALTH, no. 12, 15 December 2015 (2015-12-15), pages 1 - 99, XP055931735
TAN K. S.: "CNPase, a 2',3'-Cyclic-nucleotide 3'-phosphodiesterase, as a Therapeutic Target to Attenuate Cardiac Hypertrophy by Enhancing Mitochondrial Energy Production", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, no. 19, 6 October 2021 (2021-10-06), pages 1 - 15, XP055931789
WANG DONGFANG; TAN KEAI SINN; ARIAS-MORENO XABIER; TAN WEN; CHENG GUOHUA: "Sirt3 increases CNPase enzymatic activity through deacetylation and facilitating substrate accessibility", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 571, 27 July 2021 (2021-07-27), Amsterdam NL , pages 181 - 187, XP086754306, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2021.07.079
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