Title:
METHOD FOR PREPARING D-CHIRO-INOSITOL USING MICROBES
Document Type and Number:
WIPO Patent Application WO/2014/051358
Kind Code:
A1
Abstract:
The present invention relates to a method for preparing D-chiro-inositol from myo-inositol by using a transformed host cell which expresses enzymes such as a myo-inositol transporter, inositol dehydrogenase, and inosose isomerase. According to the method of the present invention, myo-inositol can be converted into D-chiro-inositol at a high yield.
Inventors:
MYEONG HYUN KOON (KR)
YOON SANG-HWAL (KR)
LEE HYEON-SEO (KR)
YOON SANG-HWAL (KR)
LEE HYEON-SEO (KR)
Application Number:
PCT/KR2013/008637
Publication Date:
April 03, 2014
Filing Date:
September 26, 2013
Export Citation:
Assignee:
SOLGENT CO (KR)
International Classes:
C12N15/52; C12N1/21; C12N15/63; C12P7/18
Domestic Patent References:
| WO2002055715A1 | 2002-07-18 | |||
| WO1996025381A1 | 1996-08-22 | |||
| WO2002055715A1 | 2002-07-18 | |||
| WO2002055715A1 | 2002-07-18 |
Foreign References:
| JP2006141216A | 2006-06-08 | |||
| US5827896A | 1998-10-27 | |||
| US5091596A | 1992-02-25 | |||
| US5463142A | 1995-10-31 | |||
| US5714643A | 1998-02-03 | |||
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| US4482761A | 1984-11-13 | |||
| US5096594A | 1992-03-17 | |||
| US5482631A | 1996-01-09 | |||
| KR100753982B1 | 2007-08-31 |
Other References:
KEN-ICHI YOSHIDA ET AL.: "GENETIC MODIFICATION OF BACILLUS SUBTILIS FOR PRODUCTION OF D-CHIRO-INOSITOL, ANINVESTIGATIONAL DRUG CANDIDATE FOR TREATMENT OF TYPE 2 DIABETES AND POLYCYSTIC OVARY SYNDROME", APPLIED AND ENVIRONMENTAL MICROBIOLOGY., vol. 72, no. 2, 2006, pages 1310 - 1315, XP008147399
DATABASE GENBANK [online] 20 August 2012 (2012-08-20), "MAJOR MYO-INOSITOL TRANSPORTER IOLT [BACILLUS SUBTILIS SUBSP. SUBTILIS STR. 168]", XP055240918, accession no. NCBI Database accession no. NP_388504.1
DATABASE GENBANK [online] 23 May 2011 (2011-05-23), "MYO-INOSITOL 2-DEHYDROGENASE [AGROBACTERIUM SP. ATCC 31749]", XP055240920, accession no. NCBI Database accession no. EGL61813.1
DESHUSSES, J.; REBER, G, BIOCHIM. BIOPHYS. ACTA, 1972, pages 274
BACTERIOL., vol. 126, pages 243 - 250
REBER, G.; BELET, M.; DESHUSSES, J., J. BACTEROL., vol. 131, 1977, pages 872 - 875
GAUCHAT-FEISS, D.; FREY, J.; BELET, M.; DESHUSSES, J., J. BACTERIOL., vol. 162, 1985, pages 324 - 327
NIKAWA, J.; NAGUMO, T.; YAMASHITA, S., J. BACTERIOL., vol. 150, 1982, pages 441 - 446
BERMAN T; MAGASANIK B, J. BIOL. CHEM., vol. 241, no. 4, 1966, pages 800 - 806
LARNER J; JACKSON WT; GRAVES DJ; STAMER JR, ARCH. BIOCHEM. BIOPHYS., vol. 60, no. 2, 1956, pages 352 - 363
VIDAL-LEIRIA M; VAN UDEN N, BIOCHIM. BIOPHYS. ACTA, vol. 293, no. 2, 1973, pages 295 - 303
SAMBROOK: "Molecular Cloning, A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
YANOFSKY, C., J. BACTERIOL., vol. 158, 1984, pages 1018 - 1024
HERSKOWITZ; HAGEN, D., ANN. REV. GENET., vol. 14, 1980, pages 399 - 445
COHEN, S.N. ET AL., PROC. NATL, ACAC. SCI. USA, vol. 9, 1973, pages 2110 - 2114
HANAHAN, D., J. MOL. BIOL., vol. 166, 1983, pages 557 - 580
DOWER, W.J., NUCLEIC.ACIDS RES., vol. 16, 1988, pages 6127 - 6145
YOSHIDA ET AL., AEM72, 2006
DATABASE GENBANK [online] 20 August 2012 (2012-08-20), "MAJOR MYO-INOSITOL TRANSPORTER IOLT [BACILLUS SUBTILIS SUBSP. SUBTILIS STR. 168]", XP055240918, accession no. NCBI Database accession no. NP_388504.1
DATABASE GENBANK [online] 23 May 2011 (2011-05-23), "MYO-INOSITOL 2-DEHYDROGENASE [AGROBACTERIUM SP. ATCC 31749]", XP055240920, accession no. NCBI Database accession no. EGL61813.1
DESHUSSES, J.; REBER, G, BIOCHIM. BIOPHYS. ACTA, 1972, pages 274
BACTERIOL., vol. 126, pages 243 - 250
REBER, G.; BELET, M.; DESHUSSES, J., J. BACTEROL., vol. 131, 1977, pages 872 - 875
GAUCHAT-FEISS, D.; FREY, J.; BELET, M.; DESHUSSES, J., J. BACTERIOL., vol. 162, 1985, pages 324 - 327
NIKAWA, J.; NAGUMO, T.; YAMASHITA, S., J. BACTERIOL., vol. 150, 1982, pages 441 - 446
BERMAN T; MAGASANIK B, J. BIOL. CHEM., vol. 241, no. 4, 1966, pages 800 - 806
LARNER J; JACKSON WT; GRAVES DJ; STAMER JR, ARCH. BIOCHEM. BIOPHYS., vol. 60, no. 2, 1956, pages 352 - 363
VIDAL-LEIRIA M; VAN UDEN N, BIOCHIM. BIOPHYS. ACTA, vol. 293, no. 2, 1973, pages 295 - 303
SAMBROOK: "Molecular Cloning, A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
YANOFSKY, C., J. BACTERIOL., vol. 158, 1984, pages 1018 - 1024
HERSKOWITZ; HAGEN, D., ANN. REV. GENET., vol. 14, 1980, pages 399 - 445
COHEN, S.N. ET AL., PROC. NATL, ACAC. SCI. USA, vol. 9, 1973, pages 2110 - 2114
HANAHAN, D., J. MOL. BIOL., vol. 166, 1983, pages 557 - 580
DOWER, W.J., NUCLEIC.ACIDS RES., vol. 16, 1988, pages 6127 - 6145
YOSHIDA ET AL., AEM72, 2006
Attorney, Agent or Firm:
YANG, Boo-Hyun (Chungdong Building1659-2 Inhundong,,Gwanak-gu, Seoul 151-832, KR)
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