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Title:
METHOD FOR PREPARING GYNOSTEMMA PENTAPHYLLA MAKINO SAPONIN LVI, XLVI, L, LI, DAMULIN A OR DAMULIN B
Document Type and Number:
WIPO Patent Application WO/2019/178980
Kind Code:
A1
Abstract:
A method for preparing gynostemma pentaphylla makino saponin LVI, XLVI, L, LI, Damulin A or Damulin B. In said method, Gynostemma cardiospermum Cogn.ex Oliv is used as a raw material to prepare a high content of target product by means of extraction and purification. The raw material is easy to obtain, and the cost is low. In addition, using cunninghamella blakesleeana AS3.153 strain to respectively convert gynostemma pentaphylla makino saponin LI and L to Damulin A and Damulin B by means of a microbial conversion method is also disclosed, and said method has a high conversion rate.

Inventors:
LOU ZHICHUN (CN)
Application Number:
PCT/CN2018/093947
Publication Date:
September 26, 2019
Filing Date:
July 01, 2018
Export Citation:
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Assignee:
LOU ZHICHUN (CN)
International Classes:
C07J17/00; C07H1/08; C07H15/256; C07J9/00; C12P33/00; C12R1/645
Domestic Patent References:
WO2011007943A12011-01-20
Foreign References:
CN108178778A2018-06-19
CN108179169A2018-06-19
CN103908486A2014-07-09
CN102552371A2012-07-11
CN103169725A2013-06-26
CN103720740A2014-04-16
KR101450571B12014-10-15
Other References:
LIU, HUIMIN ET AL.: "Saponins from Zhung-Medicine Gocaekmbaw before and after heat-Processing", CHINESE JOURNAL OF EXPERIMENTAL TRAD. MEDICAL FORMULAE, vol. 19, no. 15, 31 August 2013 (2013-08-31), pages 106 - 110, XP055640380
PIAO, XIANGLAN ET AL.: "Microbial Transformation of Ethanol-Soluble Constituents from Gynostemma Pentaphyllum", FOOD SCIENCE, vol. 34, no. 21, 201331231, pages 149 - 153, XP055640387
LIU, HUIMIN ET AL.: "Microbial Transformation of Gypenoside XL VI by Lactobacillus Delbrueckii Subsp. Bulgaricus", FOOD SCIENCE, vol. 35, no. 17, 31 December 2014 (2014-12-31), pages 133 - 136
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