Title:
METHOD FOR PREPARING HYALURONIC ACID HYDROGEL MIROPARTICLES AND USE THEREOF IN REPAIRING ARTICULAR CARTILAGE DEFECTS
Document Type and Number:
WIPO Patent Application WO/2019/178825
Kind Code:
A1
Abstract:
A method for preparing hyaluronic acid hydrogel microparticles and a use thereof in repairing articular cartilage defects, the method for preparing hyaluronic acid hydrogel microparticles comprising: (a) reacting hyaluronic acid with methacrylic anhydride to synthesize a methacrylated hyaluronic acid conjugate; (b) mixing the methacrylated hyaluronic acid conjugate with a photoinitiator, and irradiating ultraviolet light to carry out a photopolymerization reaction so as to obtain a hyaluronic acid hydrogel; and (c) passing the hyaluronic acid hydrogel through a sieve to obtain hyaluronic acid hydrogel microparticles.
Inventors:
HO MEI-LING (CN)
CHANG JE-KEN (CN)
CHEN CHUNG-HWAN (CN)
CHEN HUI-TING (CN)
WU SHUN CHENG (CN)
TEONG BENJAMIN (CN)
CHANG JE-KEN (CN)
CHEN CHUNG-HWAN (CN)
CHEN HUI-TING (CN)
WU SHUN CHENG (CN)
TEONG BENJAMIN (CN)
Application Number:
PCT/CN2018/080135
Publication Date:
September 26, 2019
Filing Date:
March 23, 2018
Export Citation:
Assignee:
UNIV KAOHSIUNG MEDICAL (CN)
International Classes:
C08B37/08; A61L27/52; C08F2/48; C08F299/00; C08J3/075; C08J3/24; C08J3/28
Foreign References:
| CN104788583A | 2015-07-22 | |||
| CN103877614A | 2014-06-25 | |||
| CN103724455A | 2014-04-16 | |||
| TW201306849A | 2013-02-16 |
Other References:
See also references of EP 3770181A4
Attorney, Agent or Firm:
xWINGUAN PATENT AND TRADEMARK ATTORNEYS (CN)
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