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Title:
METHOD FOR PREPARING HYALURONIC ACID HYDROGEL MIROPARTICLES AND USE THEREOF IN REPAIRING ARTICULAR CARTILAGE DEFECTS
Document Type and Number:
WIPO Patent Application WO/2019/178825
Kind Code:
A1
Abstract:
A method for preparing hyaluronic acid hydrogel microparticles and a use thereof in repairing articular cartilage defects, the method for preparing hyaluronic acid hydrogel microparticles comprising: (a) reacting hyaluronic acid with methacrylic anhydride to synthesize a methacrylated hyaluronic acid conjugate; (b) mixing the methacrylated hyaluronic acid conjugate with a photoinitiator, and irradiating ultraviolet light to carry out a photopolymerization reaction so as to obtain a hyaluronic acid hydrogel; and (c) passing the hyaluronic acid hydrogel through a sieve to obtain hyaluronic acid hydrogel microparticles.

Inventors:
HO, Mei-Ling (No.100, Shihcyuan 1st Rd. Sanmin Dist, Kaohsiung Taiwan 807, 807, CN)
CHANG, Je-Ken (No.100, Shihcyuan 1st Rd. Sanmin Dist, Kaohsiung Taiwan 807, 807, CN)
CHEN, Chung-Hwan (No.100, Shihcyuan 1st Rd. Sanmin Dist, Kaohsiung Taiwan 807, 807, CN)
CHEN, Hui-Ting (No.100, Shihcyuan 1st Rd. Sanmin Dist, Kaohsiung Taiwan 807, 807, CN)
WU, Shun Cheng (No.100, Shihcyuan 1st Rd. Sanmin Dist, Kaohsiung Taiwan 807, 807, CN)
TEONG, Benjamin (No.100, Shihcyuan 1st Rd. Sanmin Dist, Kaohsiung Taiwan 807, 807, CN)
Application Number:
CN2018/080135
Publication Date:
September 26, 2019
Filing Date:
March 23, 2018
Export Citation:
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Assignee:
KAOHSIUNG MEDICAL UNIVERSITY (No.100, Shihcyuan 1st Rd. Sanmin Dist, Kaohsiung Taiwan 807, 807, CN)
International Classes:
C08B37/08; A61L27/52; C08F2/48; C08F299/00; C08J3/075; C08J3/24; C08J3/28
Foreign References:
CN104788583A2015-07-22
CN103877614A2014-06-25
CN103724455A2014-04-16
TW201306849A2013-02-16
Attorney, Agent or Firm:
xWINGUAN PATENT AND TRADEMARK ATTORNEYS (607 23 Sicheng Road, Tianhe DistrictGuangzhou, Guangdong 3, 510663, CN)
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