Title:
A METHOD FOR PREPARING AN INTERMEDIATE OF IOPROMIDE
Document Type and Number:
WIPO Patent Application WO/2015/060657
Kind Code:
A1
Abstract:
The present invention relates to a method for preparing an intermediate of iopromide, and more particularly, to a method for preparing an intermediate of iopromide, in which 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid dichloride is produced using 1,4-dioxane as a reaction solvent, and then reacted with 3-amino-1,2-propanediol using a solvent mixture of 1,4-dioxane or tetrahydrofuran (THF) and isopropanol as a reaction solvent to obtain the intermediate of iopromide with a faster reaction time, a smaller amount of solvent, and a higher yield.
Inventors:
JIN YONG SUK (KR)
KIM WOL YOUNG (KR)
LEE JOON HWAN (KR)
KIM SEUNG TAE (KR)
KIM SANG HYUN (KR)
YOON HEE KYOON (KR)
KIM WOL YOUNG (KR)
LEE JOON HWAN (KR)
KIM SEUNG TAE (KR)
KIM SANG HYUN (KR)
YOON HEE KYOON (KR)
Application Number:
PCT/KR2014/009991
Publication Date:
April 30, 2015
Filing Date:
October 23, 2014
Export Citation:
Assignee:
DAE WOONG PHARMA (KR)
International Classes:
C07C231/02; C07B43/06; C07C233/15
Domestic Patent References:
| WO1998054124A1 | 1998-12-03 | |||
| WO1998024757A1 | 1998-06-11 |
Foreign References:
| KR20090114729A | 2009-11-04 | |||
| KR20000061780A | 2000-10-25 | |||
| US4364921A | 1982-12-21 |
Attorney, Agent or Firm:
SON, Min (STX R&D Center 6th Floor, 163, YangJaeCheon-ro,Gangnam-gu, Seoul 135-855, KR)
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