Title:
METHOD FOR PREPARING INTERMEDIATE FOR ODANACATIB
Document Type and Number:
WIPO Patent Application WO/2017/050092
Kind Code:
A1
Abstract:
Provided is a method for preparing an intermediate of formula II for odanacatib, comprising a step of reducing the compound of formula II to a compound of formula IA, wherein the reduction is performed by adding a metal chloride and a metal borohydride to a solvent in which the compound of formula II is dissolved. The preparation method is cost-effective, simple to operate, and easy for separation and purification of the product.
Inventors:
MAO HUI (CN)
CHEN GUOCAI (CN)
SUN SHAOGUANG (CN)
HUANG JINKUN (CN)
CHEN GUOCAI (CN)
SUN SHAOGUANG (CN)
HUANG JINKUN (CN)
Application Number:
PCT/CN2016/097172
Publication Date:
March 30, 2017
Filing Date:
August 29, 2016
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
SUNCADIA PHARMACEUTICALS CO LTD (CN)
SUNCADIA PHARMACEUTICALS CO LTD (CN)
International Classes:
C07C303/30; C07C253/30; C07C255/46; C07C309/76
Domestic Patent References:
| WO2012148555A1 | 2012-11-01 | |||
| WO2015000076A1 | 2015-01-08 |
Foreign References:
| CN1993314A | 2007-07-04 | |||
| US20120282267A1 | 2012-11-08 |
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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