Title:
METHOD FOR PREPARING INTERMEDIATE FOR SYNTHESIS OF SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONIST
Document Type and Number:
WIPO Patent Application WO/2022/080813
Kind Code:
A1
Abstract:
The present invention relates to a novel method for producing an intermediate expressed by chemical formula 5 that can be effectively used in synthesis of sphingosine-1-phosphate receptor agonist.
Inventors:
KIM SUNG WOOK (KR)
KIM KI DAE (KR)
LEE SOO MIN (KR)
LEE HO YEON (KR)
HAM JIN OK (KR)
KIM KI DAE (KR)
LEE SOO MIN (KR)
LEE HO YEON (KR)
HAM JIN OK (KR)
Application Number:
PCT/KR2021/014009
Publication Date:
April 21, 2022
Filing Date:
October 12, 2021
Export Citation:
Assignee:
LG CHEMICAL LTD (KR)
International Classes:
C07C67/307; C07C45/65; C07C45/78; C07C49/303; C07C49/345; C07C67/62; C07C69/94
Domestic Patent References:
| WO2004009582A1 | 2004-01-29 |
Foreign References:
| US20120064060A1 | 2012-03-15 | |||
| KR20140104376A | 2014-08-28 | |||
| KR20140104376A | 2014-08-28 |
Other References:
AASENG, J. E. ET AL.: "Asymmetric catalytic aziridination of dihydronaphthalenes for the preparation of substituted 2-aminotetralins", TETRAHEDRON, vol. 66, 2010, pages 9790 - 9797, XP027529577
RATH, S. K. ET AL.: "Synthesis of amides from (E)-3-(l-chloro-3,4-dihydronaphthalen-2-yl)acrylic acid and substituted amino acid esters as NorA efflux pump inhibitors of Staphylococcus aureus", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 27, 2019, pages 343 - 353, XP085583826, DOI: 10.1016/j.bmc.2018.12.008
See also references of EP 4219443A4
RATH, S. K. ET AL.: "Synthesis of amides from (E)-3-(l-chloro-3,4-dihydronaphthalen-2-yl)acrylic acid and substituted amino acid esters as NorA efflux pump inhibitors of Staphylococcus aureus", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 27, 2019, pages 343 - 353, XP085583826, DOI: 10.1016/j.bmc.2018.12.008
See also references of EP 4219443A4
Attorney, Agent or Firm:
HANSUNG INTELLECTUAL PROPERTY (KR)
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