Title:
METHOD FOR PREPARING ISOXAZINONE COMPOUND AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/214686
Kind Code:
A1
Abstract:
The present invention discloses a method for preparing an isoxazinone compound (I) and an application thereof. The method and the application thereof comprise: reacting a compound (II) and carboxylic acid (III) under the action of a dehydrating agent and a base, to obtain an isoxazinone compound (I), and then subjecting the isoxazinone compound (I) to a ring opening reaction with a salt (IV) of a protonic acid of an amino compound or R3OH (VII) under the action of a base, to give a bisamide compound (V) or an N-acyl benzoate compound (VI). The method has the advantages of low-cost and easily-available raw materials, low production cost, simple operations, and mild reactions, avoiding the problem of sulfur-containing organic acid wastewater caused by use of organic reagents such as methanesulfonyl chloride, and producing less industrial waste, the produced waste being easy to handle, and is suitable for industrial production.
Inventors:
SHENG QIUJU (CN)
GUAN BAOCHUAN (CN)
ZHANG TIANHAO (CN)
ZHANG PAN (CN)
ZHANG JINLONG (CN)
CHEN BANGCHI (CN)
GUAN BAOCHUAN (CN)
ZHANG TIANHAO (CN)
ZHANG PAN (CN)
ZHANG JINLONG (CN)
CHEN BANGCHI (CN)
Application Number:
PCT/CN2018/084009
Publication Date:
November 29, 2018
Filing Date:
April 23, 2018
Export Citation:
Assignee:
ZHEJIANG ZHUJI UNITED CHEMICALS CO LTD (CN)
International Classes:
C07D413/14; C07D401/04; C07D413/04; C07D498/04
Domestic Patent References:
| WO2003015519A1 | 2003-02-27 | |||
| WO2004067528A1 | 2004-08-12 |
Foreign References:
| CN107033135A | 2017-08-11 | |||
| CN107089970A | 2017-08-25 | |||
| CN102827145A | 2012-12-19 | |||
| CN103304508A | 2013-09-18 | |||
| CN102725275A | 2012-10-10 | |||
| CN101809006A | 2010-08-18 | |||
| US4446262A | 1984-05-01 | |||
| CN101535304A | 2009-09-16 | |||
| US4832897A | 1989-05-23 | |||
| US8927559B2 | 2015-01-06 |
Other References:
PROISL, K. ET AL.: "Fischer Indolisation of N-(a-ketoacyl)anthranilic Acids into 2-(indol-2-carboxamido)benzoic Acids and 2-indolyl-3,1-benzoxa-zin-4-ones and Their NMR Study", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 12, no. 47, 31 December 2014 (2014-12-31), pages 9650 - 9664, XP055548904, ISSN: 1477-0520
See also references of EP 3632911A4
See also references of EP 3632911A4
Attorney, Agent or Firm:
HANGZHOU QIUSHI PATENT OFFICE CO., LTD. (CN)
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