Title:
METHOD FOR PREPARING L-GLUFOSINATE BY USING PHOSPHINE REAGENT
Document Type and Number:
WIPO Patent Application WO/2024/067610
Kind Code:
A1
Abstract:
The present application provides a method for preparing L-glufosinate. The method mainly comprises the following steps: addition and rearrangement and ring-opening reactions on a ring lactone with a substituted phosphate-type phosphine reagent, and then obtaining L-glufosinate upon post-treatment. In the present application, L-glufosinate is prepared by using a method of reacting a ring lactone compound with a substituted phosphate-type compound, and a leaving group reagent is not used in the method. The method has the advantages such as short steps, high yield, and some routes not needing to be split apart since a raw material is a chiral compound.
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Inventors:
CHIEW ANSEN (CN)
LU CHENGLIANG (CN)
WANG HONGLEI (CN)
WEN ZEXING (CN)
LU CHENGLIANG (CN)
WANG HONGLEI (CN)
WEN ZEXING (CN)
Application Number:
PCT/CN2023/121636
Publication Date:
April 04, 2024
Filing Date:
September 26, 2023
Export Citation:
Assignee:
MOJIA SHANGHAI BIOTECH CO LTD (CN)
International Classes:
C07F9/30; C07C231/12; C07C235/12; C07D307/33; C07F9/32
Domestic Patent References:
| WO2020145627A1 | 2020-07-16 |
Foreign References:
| CN114585631A | 2022-06-03 | |||
| CN113316581A | 2021-08-27 | |||
| CN114958934A | 2022-08-30 | |||
| CN113316580A | 2021-08-27 |
Other References:
"Master Theses", 1 May 2020, SOUTHEAST UNIVERSITY, CN, article ZHANG, YING: "Research on Synthesis Process of Glufosinate", pages: 1 - 101, XP009553630
CHEN, CHANG'AN ET AL.: "A New Synthetic Process of Glufosinate-Ammonium", AGROCHEMICALS, 30 April 2019 (2019-04-30)
YOULI XIAO: "Syntheses of the P-Methylase Substrates of the Bialaphos Biosynthetic Pathway", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 10, no. 24, 18 December 2008 (2008-12-18), US , pages 5521 - 5524, XP093153985, ISSN: 1523-7060, DOI: 10.1021/ol802269x
CHEN, CHANG'AN ET AL.: "A New Synthetic Process of Glufosinate-Ammonium", AGROCHEMICALS, 30 April 2019 (2019-04-30)
YOULI XIAO: "Syntheses of the P-Methylase Substrates of the Bialaphos Biosynthetic Pathway", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 10, no. 24, 18 December 2008 (2008-12-18), US , pages 5521 - 5524, XP093153985, ISSN: 1523-7060, DOI: 10.1021/ol802269x
Attorney, Agent or Firm:
JUN HE LAW OFFICES (CN)
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