Title:
METHOD FOR PREPARING LONG-CHAIN COMPOUND
Document Type and Number:
WIPO Patent Application WO/2017/113502
Kind Code:
A1
Abstract:
The present invention relates to a method for preparing a long-chain compound, comprising the following steps: 1) performing a condensation reaction of H-R2 and R5N-Glu(OR4)-OR3, wherein R3 is a carboxyl protecting group, R4 is a carboxyl activating group, and R5 is an amino protecting group, to obtain a compound of formula II; 2) removing the R3 carboxyl protecting group and the R5 amino protecting group of the compound represented by formula II to obtain a compound of formula III; and 3) performing a condensation reaction between the compound represented by formula III and AA to obtain the compound represented by formula I. The method reduces numbers of deprotection times, and all the reactions can be performed in a low boiling solvent; the post-treatment only requires simple washing and recrystallization to obtain a product with a higher purity; and the method is suitable for large-scale production.
Inventors:
CHEN YOU JIN (CN)
MI PENGCHENG (CN)
TAO ANJIN (CN)
YUAN JIANCHENG (CN)
MI PENGCHENG (CN)
TAO ANJIN (CN)
YUAN JIANCHENG (CN)
Application Number:
PCT/CN2016/074876
Publication Date:
July 06, 2017
Filing Date:
February 29, 2016
Export Citation:
Assignee:
HYBIO PHARMACEUTICAL CO LTD (CN)
International Classes:
C07C231/14; C07C237/22
Foreign References:
| CN104395338A | 2015-03-04 | |||
| US20100221749A1 | 2010-09-02 |
Other References:
SULLINS, D.W. ET AL.: "Total Synthesis of the Methanogenic Cofactors Methanofuran and Methanofuran b.", J. AM. CHEM. SOC., vol. 115, no. 15, 7 January 1993 (1993-01-07), pages 6646 - 6651, XP055496847
CLAVE, G. ET AL.: "A Novel Heterotrifunctional Peptide-Based Cross-Linking Reagent for Facile Access to Bioconjugates. Applications to Peptide Fluorescent Labelling and Immobilization", ORGANIC & BIOMOLECILAR CHEMISTRY, vol. 6, no. 17, 30 June 2008 (2008-06-30), pages 3065 - 3078, XP055035016, ISSN: 1477-0520
GAO, PENG ET AL.: "Synthesis and Gelation of N-Stearoyl-L-Glutamic Acid and N-Stearoyl-L-Glutamic Diethyl Ester", ACTA CHIMICA SINICA, vol. 62, no. 9, 30 September 2004 (2004-09-30), pages 895 - 900, XP009507385, ISSN: 0567-7351
See also references of EP 3398933A4
CLAVE, G. ET AL.: "A Novel Heterotrifunctional Peptide-Based Cross-Linking Reagent for Facile Access to Bioconjugates. Applications to Peptide Fluorescent Labelling and Immobilization", ORGANIC & BIOMOLECILAR CHEMISTRY, vol. 6, no. 17, 30 June 2008 (2008-06-30), pages 3065 - 3078, XP055035016, ISSN: 1477-0520
GAO, PENG ET AL.: "Synthesis and Gelation of N-Stearoyl-L-Glutamic Acid and N-Stearoyl-L-Glutamic Diethyl Ester", ACTA CHIMICA SINICA, vol. 62, no. 9, 30 September 2004 (2004-09-30), pages 895 - 900, XP009507385, ISSN: 0567-7351
See also references of EP 3398933A4
Attorney, Agent or Firm:
BEIJING CHENGHUI LAW FIRM (CN)
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