Title:
METHOD FOR PREPARING MONTELUKAST SODIUM SALTS
Document Type and Number:
WIPO Patent Application WO/2010/036048
Kind Code:
A2
Abstract:
The present invention provides a method for preparing montelukast sodium salts of chemical formula 1 in the Description. The method of the present invention comprises the steps of: coupling the methanesulfonyl of chemical formula 2 and the compound of chemical formula 3 in the presence of bis(trimethylsilyl)amide alkali metal salts, adding an alkali metal base, and heating and hydrolyzing the resultant material to produce the compound of chemical formula 4; enabling a reaction between the compound of chemical formula 4 and 4-tert-butylcyclohexylamine and refining the resultant to produce the amine salts of chemical formula 5; and converting the amine salts into sodium salts.
Inventors:
LEE, In Sang (Research Centers, LG Life Sciences Ltd.,104-1, Monji-dong, Yuseong-gu, Daejeon 305-380, 305-380, KR)
이인상 (대전광역시 유성구 문지동 104-1번지 주식회사 엘지생명과학 기술연구원, 305-380 Daejeon, 305-380, KR)
LEE, Seok Ju (Research Centers, LG Life Sciences Ltd.,104-1, Monji-dong, Yuseong-gu, Daejeon 305-380, 305-380, KR)
이인상 (대전광역시 유성구 문지동 104-1번지 주식회사 엘지생명과학 기술연구원, 305-380 Daejeon, 305-380, KR)
LEE, Seok Ju (Research Centers, LG Life Sciences Ltd.,104-1, Monji-dong, Yuseong-gu, Daejeon 305-380, 305-380, KR)
Application Number:
KR2009/005472
Publication Date:
April 01, 2010
Filing Date:
September 25, 2009
Export Citation:
Assignee:
LG LIFE SCIENCES, LTD. (LG Twin Tower, 20 Yoido-dong, Youngdungpo-gu, Seoul 150-721, 150-721, KR)
주식회사 엘지생명과학 (서울특별시 영등포구 여의도동 20번지 엘지트윈타워, 150-721 Seoul, 150-721, KR)
LEE, In Sang (Research Centers, LG Life Sciences Ltd.,104-1, Monji-dong, Yuseong-gu, Daejeon 305-380, 305-380, KR)
이인상 (대전광역시 유성구 문지동 104-1번지 주식회사 엘지생명과학 기술연구원, 305-380 Daejeon, 305-380, KR)
주식회사 엘지생명과학 (서울특별시 영등포구 여의도동 20번지 엘지트윈타워, 150-721 Seoul, 150-721, KR)
LEE, In Sang (Research Centers, LG Life Sciences Ltd.,104-1, Monji-dong, Yuseong-gu, Daejeon 305-380, 305-380, KR)
이인상 (대전광역시 유성구 문지동 104-1번지 주식회사 엘지생명과학 기술연구원, 305-380 Daejeon, 305-380, KR)
International Classes:
C07D215/18
Attorney, Agent or Firm:
SOHN, Chang Kyu (1403, Seongji Heights 2-cha Bldg.642-16, Yoksam 1-dong, Kangnam-gu, Seoul 135-910, 135-910, KR)
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