Title:
METHOD FOR PREPARING MUTANT STRAIN HAVING HIGH PRODUCIBILITY OF PHYTOENE AND MUTANT STRAIN PREPARED THEREBY
Document Type and Number:
WIPO Patent Application WO/2018/182334
Kind Code:
A1
Abstract:
The present invention relates to a method for preparing a mutant strain having high producibility of phytoene and a mutant strain prepared thereby. More particularly, a Deinococcus radiodurans mutant strain, prepared by the method of the present invention, having high producibility of phytoene, does not retain an artificial antibiotic-resistant gene, although constructed by introducing a metabolism engineering method, and has high producibility of phytoene. Thus, the mutant strain prepared according to the method can find useful applications in the mass production of phytoene.
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Inventors:
CHOI YONG JUN (KR)
JEONG SUN WOOK (KR)
KIM JUA (KR)
LIM YOUNGHOON (KR)
HONG EUNKYUNG (KR)
CHO KWANG JIN (KR)
JEONG SUN WOOK (KR)
KIM JUA (KR)
LIM YOUNGHOON (KR)
HONG EUNKYUNG (KR)
CHO KWANG JIN (KR)
Application Number:
PCT/KR2018/003725
Publication Date:
October 04, 2018
Filing Date:
March 29, 2018
Export Citation:
Assignee:
UNIV SEOUL IND COOP FOUND (KR)
International Classes:
C12N15/74; C12N15/64; C12P5/02
Foreign References:
| KR20110032375A | 2011-03-30 | |||
| KR100813284B1 | 2008-03-13 |
Other References:
XU, Z.: "Identification and functional analysis of a phytoene desaturase gene from the extremely radioresistant bacterium Deinococcus radiodurans", MICROBIOLOGY, 2007, pages 1642 - 1652, XP055347525, DOI: doi:10.1099/mic.0.2006/002857-0
SATOH, K.: "Development of versatile shuttle vectors for Deinococcus grandis", PLASMID, vol. 62, no. 1, 9 January 2009 (2009-01-09), pages 1 - 9, XP026145052
NGUYEN, H. H.: "The essential histone-like protein HU plays a major role in Deinococcus radiodurans nucleoid compaction", MOLECULAR MICROBIOLOGY, vol. 73, no. 2, 28 June 2009 (2009-06-28) - 10 July 2009 (2009-07-10), pages 240 - 252, XP055612519
DATABASE NUCLEOTIDE 6 May 2016 (2016-05-06), ANONYMOUS: "Deinococcus radiodurans R1 chromosome 1, complete sequence", XP055612524, retrieved from NCBI Database accession no. CP015081
TIAN, B.: "Carotenoid biosynthesis in extremophilic Deinococcus-Thermus bacteria", TRENDS IN MICROBIOLOGY, vol. 18, no. 11, November 2010 (2010-11-01), pages 512 - 520, XP027435068
CHOW, K.-S.: "Insights into rubber biosynthesis from transcriptome analysis of Hevea brasiliens is latex", JOURNAL OF EXPERIMENTAL BOTANY, 2007, pages 2429 - 2440, XP002521158, DOI: doi:10.1093/JXB/ERM093
"NCBI GeneBank", Database accession no. 1800077
H. H. NGUYEN ET AL., MOLECULAR MICROBIOLOGY, vol. 73, no. 2, 2009, pages 240 - 252
SATOH K. ET AL., MICROBIOLOGY, vol. 152, 2006, pages 3217 - 3226
MEIMA R., APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 66, 2000, pages 3856 - 3867
NGUYEN, H. H. ET AL., MOLECULAR MICROBIOLOGY, vol. 73, 2009, pages 240 - 252
MEIMA R.LIDSTROM M. E., APPLIED ENVIRONMENTAL MICROBIOLOGY, vol. 66, pages 3856 - 3867
See also references of EP 3611267A4
SATOH, K.: "Development of versatile shuttle vectors for Deinococcus grandis", PLASMID, vol. 62, no. 1, 9 January 2009 (2009-01-09), pages 1 - 9, XP026145052
NGUYEN, H. H.: "The essential histone-like protein HU plays a major role in Deinococcus radiodurans nucleoid compaction", MOLECULAR MICROBIOLOGY, vol. 73, no. 2, 28 June 2009 (2009-06-28) - 10 July 2009 (2009-07-10), pages 240 - 252, XP055612519
DATABASE NUCLEOTIDE 6 May 2016 (2016-05-06), ANONYMOUS: "Deinococcus radiodurans R1 chromosome 1, complete sequence", XP055612524, retrieved from NCBI Database accession no. CP015081
TIAN, B.: "Carotenoid biosynthesis in extremophilic Deinococcus-Thermus bacteria", TRENDS IN MICROBIOLOGY, vol. 18, no. 11, November 2010 (2010-11-01), pages 512 - 520, XP027435068
CHOW, K.-S.: "Insights into rubber biosynthesis from transcriptome analysis of Hevea brasiliens is latex", JOURNAL OF EXPERIMENTAL BOTANY, 2007, pages 2429 - 2440, XP002521158, DOI: doi:10.1093/JXB/ERM093
"NCBI GeneBank", Database accession no. 1800077
H. H. NGUYEN ET AL., MOLECULAR MICROBIOLOGY, vol. 73, no. 2, 2009, pages 240 - 252
SATOH K. ET AL., MICROBIOLOGY, vol. 152, 2006, pages 3217 - 3226
MEIMA R., APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 66, 2000, pages 3856 - 3867
NGUYEN, H. H. ET AL., MOLECULAR MICROBIOLOGY, vol. 73, 2009, pages 240 - 252
MEIMA R.LIDSTROM M. E., APPLIED ENVIRONMENTAL MICROBIOLOGY, vol. 66, pages 3856 - 3867
See also references of EP 3611267A4
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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