Title:
METHOD FOR PREPARING N-SULFIMIDE
Document Type and Number:
WIPO Patent Application WO/2022/261992
Kind Code:
A1
Abstract:
Disclosed in the present invention is a method for preparing N-sulfimide, the method comprising: using ferric sulfate as a catalyst or using no catalyst and potassium hydrogen sulfate as an auxiliary agent to achieve a reaction of three components, i.e. an amide, sulfanilamide and ethyl diazoacetate, to prepare the N-sulfimide. The method has the following advantages: the catalyst is cheap and green, the reaction is more economical, the universality of the substrate is broad, the raw materials are readily available, and the method can be carried out in air, has a simple and convenient post-treatment, and is beneficial for application in pharmaceutical molecule synthesis and large-scale industrialization. In addition, the reactants, catalyst, auxiliary agent, etc. used in the present invention are cheap and readily available, the reaction composition is rational, no ligand or toxic metal catalyst is required, the atomic economy is high, there are few reaction steps, a relatively high yield can be obtained simply by means of a one-step reaction, and the requirement and direction of the contemporary green chemistry and pharmaceutical chemistry are met.
Inventors:
WAN XIAOBING (CN)
LI BINGBING (CN)
ZHAO YANWEI (CN)
YANG JINWEI (CN)
LI RUYI (CN)
CAO ZHIYU (CN)
LI BINGBING (CN)
ZHAO YANWEI (CN)
YANG JINWEI (CN)
LI RUYI (CN)
CAO ZHIYU (CN)
Application Number:
PCT/CN2021/101095
Publication Date:
December 22, 2022
Filing Date:
June 18, 2021
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
C07C303/36; B01J23/745; B01J23/75; C07C303/00; C07C311/50; C07C311/51
Foreign References:
| CN107459509A | 2017-12-12 | |||
| CN108147981A | 2018-06-12 | |||
| CN110615811A | 2019-12-27 |
Other References:
NIKOLAEV VSEVOLOD, HENNIG LOTHAR, SIELER JOCHIM, RODINA LUDMILA, SCHULZE BARBEL, NIKOLAEV VALERIJ: "Cyclic and acyclic sulfonimides in reactions with Rh(ii)-ketocarbenoids: a new access to chemoselective O-functionalization of the imidic carbonyl groups", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 3, no. 22, 1 January 2005 (2005-01-01), pages 4108 - 4116, XP093014945, ISSN: 1477-0520, DOI: 10.1039/b508317f
A. V. SELIVANOVA ; V. V. NIKOLAEV ; R. R. KOSTIKOV ; V. A. NIKOLAEV ; J. SILER ; B. SCHULZE: "Chemistry of diazocarbonyl compounds: XXVIII. Reaction of acyclic N-arylsulfonylacetamides with Rh(II)-carbenoids as a new synthetic route to alkyl acetimidoates", RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, vol. 42, no. 12, 1 December 2006 (2006-12-01), Mo , pages 1792 - 1799, XP019468142, ISSN: 1608-3393, DOI: 10.1134/S1070428006120074
A. V. SELIVANOVA ; V. V. NIKOLAEV ; R. R. KOSTIKOV ; V. A. NIKOLAEV ; J. SILER ; B. SCHULZE: "Chemistry of diazocarbonyl compounds: XXVIII. Reaction of acyclic N-arylsulfonylacetamides with Rh(II)-carbenoids as a new synthetic route to alkyl acetimidoates", RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, vol. 42, no. 12, 1 December 2006 (2006-12-01), Mo , pages 1792 - 1799, XP019468142, ISSN: 1608-3393, DOI: 10.1134/S1070428006120074
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (CN)
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