METHOD FOR PREPARING NANOPARTICLES OF TOTAL EOMECON CHIONANTHA ALKALOID

Title:

METHOD FOR PREPARING NANOPARTICLES OF TOTAL EOMECON CHIONANTHA ALKALOID

Document Type and Number:

WIPO Patent Application WO/2020/211264

Kind Code:

A1

Abstract:

Provided is a method for preparing nanoparticles of a total Eomecon chionantha alkaloid. The preparation steps are as follows: a) crushing the medicinal parts of Eomecon chionantha, mixing same with an alkaline substance, adding water and mixing same uniformly, and leaving same to stand overnight; b) adjusting the pH, collecting precipitates, carrying out drying, performing alcohol extraction, and performing concentration and filtration; c) spraying the filtrate, which has been refrigerated, in reverse into a supercritical crystallization kettle for preparation; and d) collecting the nanoparticles at the bottom. In the present method, alkaloids are converted into ion pairs, and upon filtration, the total alkaloid content of the product reaches at least 60%. The obtained nanoparticles have a minimum diameter of 500 nm and a body part of 1-15 μm, and can be applied to the fields of feed additives, medicines and foods.

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Inventors:

LI XIAODONG (CN)
TAN MANLIANG (CN)
LI JUNTAO (CN)
YANG YINGSHI (CN)
QI SHUYANG (CN)
YOU YALI (CN)
JIANG JIAYANG (CN)

Application Number:

PCT/CN2019/104655

Publication Date:

October 22, 2020

Filing Date:

September 06, 2019

Export Citation:

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Assignee:

NANJING KANGQI BIOTECHNOLOGY CO LTD (CN)

International Classes:

A61K36/66; A23K10/30; A23L33/105; A61K9/16; A61P33/00

Foreign References:

CN110141605A	2019-08-20
CN101953898A	2011-01-26
CN101491589A	2009-07-29
CN1457780A	2003-11-26

Attorney, Agent or Firm:

SUZHOU WUYUN INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)

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