Title:
METHOD FOR PREPARING NICOTINE OF HIGH OPTICAL PURITY
Document Type and Number:
WIPO Patent Application WO/2022/105482
Kind Code:
A1
Abstract:
Disclosed is a method for preparing nicotine of a high optical purity, wherein biological enzyme catalysis technology is used to achieve directional reduction of an intermediate product, myosmine; the intermediate product myosmine can be reduced and hydrogenated and converted into a single chirality; and L-nicotine of a high yield and a high optical purity is then obtained by means of a methylation reaction. The L-nicotine has a chiral purity of up to 99%, and can be directly used for preparing downstream products. Enzymes used can be efficiently recycled, such that the cost is greatly reduced.
Inventors:
LI JIAQUAN (CN)
WEI GENGHUI (CN)
MENG XIANQIANG (CN)
WEI GENGHUI (CN)
MENG XIANQIANG (CN)
Application Number:
PCT/CN2021/123322
Publication Date:
May 27, 2022
Filing Date:
October 12, 2021
Export Citation:
Assignee:
SHANDONG JINCHENG PHARMACCUTICAL CHEMICAL CO LTD (CN)
SHENZHEN HANGSEN STAR TECHNOLOGY CO LTD (CN)
SHENZHEN HANGSEN STAR TECHNOLOGY CO LTD (CN)
International Classes:
C07D401/04; C12P17/16
Domestic Patent References:
| WO2020098978A1 | 2020-05-22 | |||
| WO2014174505A2 | 2014-10-30 |
Foreign References:
| CN112409327A | 2021-02-26 | |||
| CN111511726A | 2020-08-07 | |||
| US20160326134A1 | 2016-11-10 | |||
| CN107406411A | 2017-11-28 | |||
| CN102617547A | 2012-08-01 |
Attorney, Agent or Firm:
GUANG DONG ZHUOJIAN LAW FIRM (CN)
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