Title:
METHOD FOR PREPARING NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND DERIVATIVE THEREOF BY MEANS OF ENZYMATIC-CHEMICAL CASCADE METHOD
Document Type and Number:
WIPO Patent Application WO/2022/110916
Kind Code:
A1
Abstract:
A method for preparing a nitrogen-containing heterocyclic compound and a derivative thereof by means of an enzymatic-chemical cascade method, comprising: reacting an alcohol, an amine, an alcohol dehydrogenase, a flavin molecule and a coenzyme in a solvent to obtain the nitrogen-containing heterocyclic compound and the derivative thereof. Compared with the prior art, the method is a green and economical enzymatic-chemical cascade method, and is used for synthesizing nitrogen-containing heterocyclic compounds and derivatives thereof. Compared with a common toxic chemical catalyst, an alcohol dehydrogenase is selected as a catalyst, which has the characteristics of a high substrate specificity, no pollution, a high catalytic efficiency, no toxic solvents, simple post-treatments, etc. In addition, the action of the flavin molecule has two aspects: one is to form a former enzymatic regeneration system, and the other is to be used as an oxidizing agent in a later chemical method, such that no other oxidizing agents need to be added throughout the whole cascade reaction.
Inventors:
ZHU CHENJIE (CN)
YING HANJIE (CN)
TAN ZHUOTAO (CN)
ZHUANG WEI (CN)
FU YAPING (CN)
HAN YAOYING (CN)
LI MING (CN)
CHEN YONG (CN)
LIU DONG (CN)
NIU HUANQING (CN)
YANG PENGPENG (CN)
YING HANJIE (CN)
TAN ZHUOTAO (CN)
ZHUANG WEI (CN)
FU YAPING (CN)
HAN YAOYING (CN)
LI MING (CN)
CHEN YONG (CN)
LIU DONG (CN)
NIU HUANQING (CN)
YANG PENGPENG (CN)
Application Number:
PCT/CN2021/113184
Publication Date:
June 02, 2022
Filing Date:
August 18, 2021
Export Citation:
Assignee:
UNIV NANJING TECH (CN)
International Classes:
C07D235/08; C07D207/323; C07D213/16; C07D215/04; C07D235/10; C07D235/12; C07D277/66; C07D401/04; C07D405/04; C07D409/04; C12P7/24; C12P17/04
Domestic Patent References:
| WO2016159049A1 | 2016-10-06 |
Foreign References:
| CN112695062A | 2021-04-23 | |||
| CN112375040A | 2021-02-19 | |||
| CN105622693A | 2016-06-01 | |||
| CN110964764A | 2020-04-07 | |||
| CN109836377A | 2019-06-04 |
Other References:
GORAVANAHALLI M. RAGHAVENDRA; AJJAHALLI B. RAMESHA; CIGALLI N. REVANNA; KEBBAHALLI N. NANDEESH; KEMPEGOWDA MANTELINGU; KANCHUGARAK: "One-pot tandem approach for the synthesis of benzimidazoles and benzothiazoles from alcohols", TETRAHEDRON LETTERS, vol. 52, no. 43, 7 August 2011 (2011-08-07), Amsterdam , NL , pages 5571 - 5574, XP028391254, ISSN: 0040-4039, DOI: 10.1016/j.tetlet.2011.08.037
Attorney, Agent or Firm:
JIANGSU SUNDY LAW FIRM (CN)
Download PDF: