Title:
METHOD FOR PREPARING NUCLEOTIDE TRIPHOSPHATE
Document Type and Number:
WIPO Patent Application WO/2023/185814
Kind Code:
A1
Abstract:
Disclosed in the present invention is a method for preparing nucleotide triphosphate. Provided in the present invention is a method for preparing a nucleotide triphosphate triethylamine salt, the method comprising the following steps: separating the nucleotide triphosphate to be purified, the active component of which is nucleotide triphosphate as represented by formula C, by means of chromatography, and performing preparation to obtain the nucleotide triphosphate triethylamine as represented by formula D. The preparation method achieves large-scale automatic preparation of various modified and non-modified nucleotide triphosphates, and has a good universality and a high separation degree.
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Inventors:
CAI XIAORU (CN)
GUO CHUANXIN (CN)
PENG XIANGRAN (CN)
LI SONG (CN)
QIAN QIJUN (CN)
GUO CHUANXIN (CN)
PENG XIANGRAN (CN)
LI SONG (CN)
QIAN QIJUN (CN)
Application Number:
PCT/CN2023/084320
Publication Date:
October 05, 2023
Filing Date:
March 28, 2023
Export Citation:
Assignee:
MAXIRNA SHANGHAI PHARMACEUTICAL CO LTD (CN)
MAXIRNA ZHEJIANG TECH CO LTD (CN)
MAXIRNA ZHEJIANG TECH CO LTD (CN)
International Classes:
C07H21/02; C07H1/00; C07H1/06
Domestic Patent References:
| WO2016145142A1 | 2016-09-15 |
Foreign References:
| CN114736260A | 2022-07-12 | |||
| CN105026411A | 2015-11-04 | |||
| CN103974724A | 2014-08-06 |
Other References:
SENTHILVELAN ANNAMALAI, SHANMUGASUNDARAM MUTHIAN, KORE ANILKUMAR R.: "An efficient protection-free chemical synthesis of inosine 5'-nucleotides", NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, TAYLOR & FRANCIS, US, vol. 39, no. 6, 2 June 2020 (2020-06-02), US , pages 829 - 837, XP093097353, ISSN: 1525-7770, DOI: 10.1080/15257770.2019.1708388
ANNAMALAI SENTHILVELAN: "Highly regioselective methylation of inosine nucleotide: an efficient synthesis of 7-methylinosine nucleotide", NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, TAYLOR & FRANCIS, US, vol. 39, no. 7, 19 March 2020 (2020-03-19), US , pages 1011 - 1019, XP009543658, ISSN: 1525-7770, DOI: 10.1080/15257770.2020.1738457
ANNAMALAI SENTHILVELAN: "Highly regioselective methylation of inosine nucleotide: an efficient synthesis of 7-methylinosine nucleotide", NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, TAYLOR & FRANCIS, US, vol. 39, no. 7, 19 March 2020 (2020-03-19), US , pages 1011 - 1019, XP009543658, ISSN: 1525-7770, DOI: 10.1080/15257770.2020.1738457
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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