Title:
METHOD FOR PREPARING OPTICALLY ACTIVE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2013/081087
Kind Code:
A1
Abstract:
A method for preparing trans-{4-[({2-[({1-[3,5-bis(tri- fluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]-
pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}-
(ethyl)amino)methyl]cyclohexyl}acetic acid having a high optical purity from trans-{4-[({2-[({1-[3,5-bis(trifluoro- methyl)phenyl]ethyl} {5-[2-(methylthio)ethoxy]pyrimidin-2- yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)- methyl]cyclohexyl}acetic acid having a low optical purity, including a step of subjecting a salt of the starting (latter) substance with an optically inactive acid to crystallization in a solvent and then isolating the resulting crystals.
Inventors:
YAMAZAKI KOICHI (JP)
MATSUDA KENNOSUKE (JP)
OHGIYA TADAAKI (JP)
SHIBUYA KIMIYUKI (JP)
MATSUDA KENNOSUKE (JP)
OHGIYA TADAAKI (JP)
SHIBUYA KIMIYUKI (JP)
Application Number:
PCT/JP2012/081023
Publication Date:
June 06, 2013
Filing Date:
November 30, 2012
Export Citation:
Assignee:
KOWA CO (JP)
International Classes:
C07D239/47; A61K31/505; A61P3/06; C07B57/00
Domestic Patent References:
| WO2008129951A1 | 2008-10-30 |
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
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Claims: