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Title:
METHOD FOR PREPARING OSELTAMIVIR AND ISOMER THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/233562
Kind Code:
A1
Abstract:
The present invention relates to an intermediate for preparing oseltamivir and an isomer thereof. The intermediate of the present invention is prepared by means of neighboring group participation at room temperature under the conditions of mitsunobu reaction. Further, the present invention also provides a method for preparing oseltamivir and an isomer thereof by using the described intermediate or the described preparation method as a key step. The method of the present invention has advantages of high efficiency, mildness, low toxicity, high cost-efficiency, environment-friendly and the like, being suitable for industrial production.

Inventors:
CHEN HONGJUN (CN)
LIAO SHOUZHU (CN)
WANG ZHONGQING (CN)
ZENG LEI (CN)
LIU ZHUANGFENG (CN)
LUO ZHONGHUA (CN)
Application Number:
PCT/CN2018/091465
Publication Date:
December 27, 2018
Filing Date:
June 15, 2018
Export Citation:
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Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C07C319/20; C07C231/12; C07C323/61; C07D301/02; C07D303/40
Domestic Patent References:
WO2015049700A12015-04-09
WO2012121079A12012-09-13
WO2009137916A12009-11-19
WO2011047466A12011-04-28
Foreign References:
CN1759093A2006-04-12
CN106278928A2017-01-04
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