Title:
METHOD FOR PREPARING PHENYLALANINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2018/059427
Kind Code:
A1
Abstract:
Disclosed is a method for preparing 2-(2-(4-fluorobenzoyl)phenylamino)-3-(4-(2-(9H-carbazol-9-yl)ethoxy)phenyl)propanoic acid. In the method 9-carbazole ethanol mesylate and methyl 2-[2-(4-fluorobenzoyl)phenyl)amino]-3-(4-hydroxyphenyl)propionate are used as starting materials, and subjected to condensation, hydrolysis and acidification to obtain the target compound. The preparation method of the present invention is suitable for industrial production, and the target compound has a high purity.
Inventors:
LU XIANPING (CN)
LI ZHIBIN (CN)
WANG XIANGHUI (CN)
LI ZHIBIN (CN)
WANG XIANGHUI (CN)
Application Number:
PCT/CN2017/103618
Publication Date:
April 05, 2018
Filing Date:
September 27, 2017
Export Citation:
Assignee:
SHENZHEN CHIPSCREEN BIOSCIENCES LTD (CN)
International Classes:
C07D209/86; C07C229/36
Domestic Patent References:
| WO2004048333A1 | 2004-06-10 |
Foreign References:
| CN1562970A | 2005-01-12 | |||
| CN1882537A | 2006-12-20 | |||
| CN104744282A | 2015-07-01 |
Other References:
LAN, YUKUN ET AL.: "Synthesis of Novel Insulin Sensitizer Sigolide", MEDICINAL CHEMISTRY, vol. 13, no. 8, 30 August 2004 (2004-08-30), pages 718 - 720, XP009513907, ISSN: 1003-3734
See also references of EP 3524592A4
See also references of EP 3524592A4
Attorney, Agent or Firm:
SHENPAT INTELLECTUAL PROPERTY AGENCY (CN)
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