Title:
METHOD FOR PREPARING PLATELET SOLUTION REPLACED WITH ARTIFICIAL PRESERVATION SOLUTION
Document Type and Number:
WIPO Patent Application WO/2014/084263
Kind Code:
A1
Abstract:
Disclosed is a novel means for preparing a platelet solution replaced with an artificial preservation solution, said platelet solution having excellent performances of inhibiting platelet activation, recovering platelets and removing plasma. A method of the present invention for preparing a platelet solution replaced with an artificial preservation solution comprises: a filtration step for, under the conditions represented by formula (1), using a separation membrane, said separation membrane having an average pore size of 0.1 μm or more but less than 2.0 μm in the surface to be in contact with a platelet solution, cross-flow filtering the platelet solution at an inlet wall shear rate of 25-1500 s-1 to give a concentrated platelet solution; and a mixing step for mixing the concentrated platelet solution with an artificial preservation solution to give the platelet solution replaced with the artificial preservation solution.
Formula (1): 1.0×1011<(A×B)/(γ×μP)≤2.5×1013(platelets/(hr·m2·Pa)
A: concentration of platelets contained in platelet solution (platelets/mL; in the range of 8.0×107-200×107 platelets/mL)
B: filtration flow rate per area (mL/hr/m2)
γ: inlet wall shear rate (s-1)
μP: viscosity (Pa·s) of platelet solution
Inventors:
KISHIKAWA TATSUYA (JP)
OSABE MASAHIRO (JP)
UENO YOSHIYUKI (JP)
SHIMAGAKI MASAAKI (JP)
TANAKA SHIGENORI (JP)
HAYASHI TOMOYA (JP)
OSABE MASAHIRO (JP)
UENO YOSHIYUKI (JP)
SHIMAGAKI MASAAKI (JP)
TANAKA SHIGENORI (JP)
HAYASHI TOMOYA (JP)
Application Number:
PCT/JP2013/081922
Publication Date:
June 05, 2014
Filing Date:
November 27, 2013
Export Citation:
Assignee:
TORAY INDUSTRIES (JP)
JAPAN RED CROSS (JP)
JAPAN RED CROSS (JP)
International Classes:
A61K35/14; A61K35/19; A61M1/18; A61M1/34; B01D61/14; B01D63/02
Domestic Patent References:
| WO2013147001A1 | 2013-10-03 |
Foreign References:
| JP2012143554A | 2012-08-02 | |||
| JP2012176081A | 2012-09-13 | |||
| JPH08165245A | 1996-06-25 | |||
| JP2007319542A | 2007-12-13 | |||
| JP2006077136A | 2006-03-23 | |||
| JPS62290469A | 1987-12-17 | |||
| JPS5415476A | 1979-02-05 | |||
| JPS61238834A | 1986-10-24 |
Other References:
See also references of EP 2926820A4
Attorney, Agent or Firm:
TANIGAWA AND PARTNERS, PATENT FIRM (JP)
Patent business corporation mountain stream international patent firm (JP)
Patent business corporation mountain stream international patent firm (JP)
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