Title:
METHOD FOR PREPARING POLYPHENOL-POLYMER COMPOSITE COATING AND USE THEREOF IN FUNCTIONALIZATION OF MEDICAL MATERIAL
Document Type and Number:
WIPO Patent Application WO/2024/045163
Kind Code:
A1
Abstract:
A method for preparing a polyphenol-polymer composite coating, which comprises the steps of: 1) formulating a polyphenolic hydroxyl substance and a hydrophilic uncharged or hydrophilic negatively-charged polymer into a mixed solution; 2) soaking a substrate in the mixed solution; and 3) washing and drying same. The polyphenol-polymer composite coating can be used in the functionalization of medical material. The functionalization involves a hemostatic function and/or a differential adhesion function for proteins. The conditions for achieving the hemostatic function are that: the mass ratio of the polyphenolic hydroxyl substance to the hydrophilic uncharged or hydrophilic negatively-charged polymer is 1 : 2-8 and the soaking time is 0.7-4 h, so that a medical material with the hemostatic function is obtained. The conditions for achieving differential adhesion for proteins are that: the mass ratio of the polyphenolic hydroxyl substance to the hydrophilic uncharged or hydrophilic negatively-charged polymer is 1 : 0.5-15 and the soaking time is 0.5-20 h, so that a medical material with the differential adhesion function for proteins is achieved.
Inventors:
XU FU-JIAN (CN)
HU YANG (CN)
LI XIAOYUE (CN)
YANG XUE (CN)
HU YANG (CN)
LI XIAOYUE (CN)
YANG XUE (CN)
Application Number:
PCT/CN2022/116742
Publication Date:
March 07, 2024
Filing Date:
September 02, 2022
Export Citation:
Assignee:
UNIV BEIJING CHEM TECH (CN)
International Classes:
C08J7/04; A61L24/04; A61P7/04
Domestic Patent References:
| WO2021177536A1 | 2021-09-10 |
Foreign References:
| CN105218847A | 2016-01-06 | |||
| CN106474524A | 2017-03-08 | |||
| CN114767918A | 2022-07-22 | |||
| CN106794283A | 2017-05-31 | |||
| US20180147326A1 | 2018-05-31 |
Attorney, Agent or Firm:
CHONGQING XINHANG INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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