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Title:
METHOD FOR PREPARING (R)-3-(3-FLUORO-4-(1-METHYL-5,6-DIHYDRO-1,2,4-TRIAZIN-4(1H)-YL)PHENYL)-5-(SUBSTITUTED METHYL)OXAZOLIDIN-2-ONE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2011/111971
Kind Code:
A3
Abstract:
The present invention relates to a method for preparing (R)-3-(3-fluoro-4-(1-methyl-5,6-dihydro-1,2-4-triazin-4(1H)-yl)phenyl)-5-(substituted methyl)oxazolidin-2-one derivatives, which are oxazolidinone antibiotic compounds having a cyclic amidrazone group, and to intermediates thereof, and uses 3,4-difluoro-4-nitrobenzen as a starting material. According to the preparation method of the present invention, (R)-3-(3-fluoro-4-(1-methyl-5,6-dihydro-1,2-4-triazin-4(1H)-yl)phenyl)-5-(substituted methyl)oxazolidin-2-one derivatives, which are compounds that are useful as oxazolidinone antibiotics, can be prepared in high purity and high yield in a simpler manner than conventional methods.

Inventors:
CHO YOUNG LAG (KR)
BAEK SUNG YOON (KR)
CHAE SANG EUN (KR)
LEE HONG BUM (KR)
PARK TAE KYO (KR)
WOO SUNG HO (KR)
KIM YONG ZU (KR)
Application Number:
PCT/KR2011/001579
Publication Date:
January 12, 2012
Filing Date:
March 08, 2011
Export Citation:
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Assignee:
LEGOCHEM BIOSCIENCES INC (KR)
CHO YOUNG LAG (KR)
BAEK SUNG YOON (KR)
CHAE SANG EUN (KR)
LEE HONG BUM (KR)
PARK TAE KYO (KR)
WOO SUNG HO (KR)
KIM YONG ZU (KR)
International Classes:
C07D413/10; A61K31/53; A61P31/00; C07D255/02
Domestic Patent References:
WO2010036000A22010-04-01
WO2004048350A22004-06-10
WO2004056819A12004-07-08
WO2003035648A12003-05-01
Foreign References:
EP2072513A12009-06-24
EP2072514A12009-06-24
Attorney, Agent or Firm:
KWON, Oh-Sig et al. (921 Dunsan-dong, Seo-gu, Daejeon 302-120, KR)
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Claims: