Title:
METHOD FOR PREPARING SACCHARIN COMPOUND
Document Type and Number:
WIPO Patent Application WO/2022/051955
Kind Code:
A1
Abstract:
Disclosed is a method for preparing a saccharin compound. Provided is a method for preparing a saccharin compound as shown in formula (1). The method is characterized by comprising the following step: carrying out, in water in the presence of tungstate and/or tungstic acid, an oxidation reaction on a compound as shown in formula (2) and hydrogen peroxide, to obtain a saccharin compound as shown in formula (1).
Inventors:
ZHANG FULI (CN)
ZHANG TAO (CN)
ZHANG TAO (CN)
Application Number:
PCT/CN2020/114306
Publication Date:
March 17, 2022
Filing Date:
September 10, 2020
Export Citation:
Assignee:
SHANGHAI INST PHARMACEUTICAL IND (CN)
CHINA STATE INST PHARM IND (CN)
CHINA STATE INST PHARM IND (CN)
International Classes:
C07D275/06
Foreign References:
| CN111718312A | 2020-09-29 | |||
| CN111269195A | 2020-06-12 | |||
| JP2005179309A | 2005-07-07 |
Other References:
KLYUEV V.N., KORZHENEVSKII, A.B., BEREZIN, B.D.: "Structure of a thiosalicylic acid chlorination product", IZVESTIA VYSSIH UCEBNYH ZAVEDENIJ. HIMIA I HIMICESKAA TECHNOLOGIA, SOWJETUNION MINISTERSTVO VYSEGO I SREDNEGO SPECIAL'NOGO OBRAZOVANIJA, RU, vol. 9, no. 30, 31 December 1978 (1978-12-31), RU , pages 79 - 79, XP055909991, ISSN: 0579-2991
TIAN-QUN YU ET AL.: "Potassium bromide catalyzed N-S bond formation via oxidative dehydrogenation", TETRAHEDRON LETTERS, vol. 58, no. 22, 18 April 2017 (2017-04-18), XP029994385, ISSN: 0040-4039, DOI: 10.1016/j.tetlet.2017.03.065
WEN BIN JIN ET AL.: "Bioisosteric investigation of ebselen: Synthesis and in vitro characterization of 1，2-benzisothiazol-3(2H)-one derivatives as potent New Delhi metallo-β-lactamase inhibitors", BIOORGANIC CHEMISTRY, vol. 100, 25 April 2020 (2020-04-25), XP086186258, ISSN: 0045-2068, DOI: 10.1016/j.bioorg.2020.103873
SCHULTZ H S, FREYERMUTH H B, BUC S R: "NEW CATALYSTS FOR THE OXIDATION OF SULFIDES TO SULFONES WITH HYDROGEN PEROXIDE", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 28, 1 April 1963 (1963-04-01), pages 1140 - 1143, XP009020858, ISSN: 0022-3263, DOI: 10.1021/jo01039a512
"Inorganic Chemistry, 3rd Edition", 31 August 2015, CHINA MEDICAL SCIENCE PRESS, CN, ISBN: 978-7-5067-7425-3, article WANG, GUOQING: "Chapter 11: P-Block Element", pages: 352 - 353, XP009535607
"Organic Reactions for Drug Synthesis", 30 September 2012, CHINA MEDICAL SCIENCE AND TECHNOLOGY PRESS, CN, ISBN: 978-7-5067-5516-0, article YAO, QIZHENG: "Chapter 8: Oxidation Reaction", pages: 392 - 394, XP009535606
TIAN-QUN YU ET AL.: "Potassium bromide catalyzed N-S bond formation via oxidative dehydrogenation", TETRAHEDRON LETTERS, vol. 58, no. 22, 18 April 2017 (2017-04-18), XP029994385, ISSN: 0040-4039, DOI: 10.1016/j.tetlet.2017.03.065
WEN BIN JIN ET AL.: "Bioisosteric investigation of ebselen: Synthesis and in vitro characterization of 1，2-benzisothiazol-3(2H)-one derivatives as potent New Delhi metallo-β-lactamase inhibitors", BIOORGANIC CHEMISTRY, vol. 100, 25 April 2020 (2020-04-25), XP086186258, ISSN: 0045-2068, DOI: 10.1016/j.bioorg.2020.103873
SCHULTZ H S, FREYERMUTH H B, BUC S R: "NEW CATALYSTS FOR THE OXIDATION OF SULFIDES TO SULFONES WITH HYDROGEN PEROXIDE", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 28, 1 April 1963 (1963-04-01), pages 1140 - 1143, XP009020858, ISSN: 0022-3263, DOI: 10.1021/jo01039a512
"Inorganic Chemistry, 3rd Edition", 31 August 2015, CHINA MEDICAL SCIENCE PRESS, CN, ISBN: 978-7-5067-7425-3, article WANG, GUOQING: "Chapter 11: P-Block Element", pages: 352 - 353, XP009535607
"Organic Reactions for Drug Synthesis", 30 September 2012, CHINA MEDICAL SCIENCE AND TECHNOLOGY PRESS, CN, ISBN: 978-7-5067-5516-0, article YAO, QIZHENG: "Chapter 8: Oxidation Reaction", pages: 392 - 394, XP009535606
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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