METHOD FOR PREPARING SMALL SPHERICAL BY CONTROLLED PHASE SEPARATION

Title:

METHOD FOR PREPARING SMALL SPHERICAL BY CONTROLLED PHASE SEPARATION

Document Type and Number:

WIPO Patent Application WO2005035088

Kind Code:

A3

Abstract:

The present invention is related to a method for preparing small spherical particles of an active agent by providing a solution in a single liquid phase. The single liquid phase comprises an active agent, a phase separation enhancing agent, and a first solvent. A phase change is induced at a controlled rate in the solution to cause a liquid-solid phase separation of the active agent and to form a solid phase and a liquid phase. The solid phase comprises solid small spherical particles of the active agent. The liquid phase comprises the phase separation enhancing agent and the solvent. The small spherical particles are substantially spherical and having a size from about 0.01µm to about 200µm.

Inventors:

BROWN LARRY
MC GEEHAN JOHN K
RASHBA-STEP JULIA
SCOTT TERRENCE L

Application Number:

PCT/US2004/023182

Publication Date:

December 15, 2005

Filing Date:

July 19, 2004

Export Citation:

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Assignee:

BAXTER INT (US)

International Classes:

A61K9/14; A61K9/16; A61K9/50; A61K38/095; A61K38/27; A61K38/28; A61K38/54; B01J13/06; (IPC1-7): B01J13/02; A61K9/14

Foreign References:

US5300464A	1994-04-05
US6395302B1	2002-05-28
US20030007990A1	2003-01-09

Other References: