Title:
METHOD OF PREPARING SOLUTION HAVING COMPOSITION OF BIOLOGICAL COMPONENTS
Document Type and Number:
WIPO Patent Application WO/2005/028500
Kind Code:
A1
Abstract:
A method of preparing a solution comprising combining two steps of (1) a step of adsorbing a protein having a molecular weight higher than that of albumin, (2) a step of fractionating a protein having a molecular weight higher than that of albumin, and (3) a step of concentrating a protein; a method of preparing a solution comprising separating by the use of a membrane separation unit exhibiting a permeation ratio of a protein having a molecular weight less than 15 thousands to a protein having a molecular weight of 60 thousands or more of 50 or more; and a method of preparing a solution which comprises feeding a raw biological component solution and then a liquid for dilution to a separating membrane module, and allowing a part of the resultant solution to permeate through a separation membrane while circulating the solution. The method can be advantageously employed for preparing a biological component- containing solution which is suitable for the clinical proteomics using mass analysis, electrophoresis, liquid chromatography, and the like.
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Inventors:
WADA SHIGEHISA (JP)
UTSUMI JUN (JP)
FUJITA YOSHIJI (JP)
SUGAYA HIROYUKI (JP)
YAMADA SATOKO (JP)
UTSUMI JUN (JP)
FUJITA YOSHIJI (JP)
SUGAYA HIROYUKI (JP)
YAMADA SATOKO (JP)
Application Number:
PCT/JP2004/012923
Publication Date:
March 31, 2005
Filing Date:
September 06, 2004
Export Citation:
Assignee:
TORAY INDUSTRIES (JP)
WADA SHIGEHISA (JP)
UTSUMI JUN (JP)
FUJITA YOSHIJI (JP)
SUGAYA HIROYUKI (JP)
YAMADA SATOKO (JP)
WADA SHIGEHISA (JP)
UTSUMI JUN (JP)
FUJITA YOSHIJI (JP)
SUGAYA HIROYUKI (JP)
YAMADA SATOKO (JP)
International Classes:
B01D63/02; B01D69/02; C07K1/14; C12M1/00; C12P1/00; G01N1/40; (IPC1-7): C07K1/14; C12P1/00; C12M1/00
Domestic Patent References:
| WO2001072844A2 | 2001-10-04 |
Foreign References:
| JPH01230370A | 1989-09-13 | |||
| JPS6422259A | 1989-01-25 |
Other References:
AHMED N. ET AL.: "An approach to remove albumin for the proteomic analysis of low abundance biomarkers in human serum", PROTEOMICS, vol. 3, no. 10, 23 June 2003 (2003-06-23), pages 1980 - 1987, XP002986338
ROTHEMUND D.L. ET AL.: "Depletion of the highly abundant protein albumin from uman plasma using the gradiflow", PROTEOMICS, vol. 3, no. 3, March 2003 (2003-03-01), pages 279 - 287, XP002986339
See also references of EP 1661906A4
ROTHEMUND D.L. ET AL.: "Depletion of the highly abundant protein albumin from uman plasma using the gradiflow", PROTEOMICS, vol. 3, no. 3, March 2003 (2003-03-01), pages 279 - 287, XP002986339
See also references of EP 1661906A4
Attorney, Agent or Firm:
Iwami, Tomonori c/o Intellectual Property Department TORAY INDUSTRIES (INC. 1-1, Sonoyama 1-chome, Otsu-sh, Shiga 58, JP)
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