Title:
METHOD FOR PREPARING SUCRALOSE CRUDE PRODUCT BY USING SUCRALOSE-6-ACETATE CRYSTALLIZATION MOTHER LIQUOR
Document Type and Number:
WIPO Patent Application WO/2024/082158
Kind Code:
A1
Abstract:
Provided in the present invention is a method for preparing a sucralose crude product by using a sucralose-6-acetate crystallization mother liquor. In the present invention, by using an alkali metal hydroxide for alkaline hydrolysis, sucralose-6-acetate can be subjected to alkaline hydrolysis, thereby converting sucralose-6-acetate, sucralose diester and tetrachlorosaccharose-6-acetate, which remain in the crystallization mother liquor, into sucralose, such that the yield of sucralose is significantly improved; water-soluble impurities and fat-soluble impurities in a system can be effectively separated by means of a method of mutual extraction-back extraction-recycling of an ethyl-acetate-water double-solvent system, such that sufficient crystallization of sucralose in ethyl acetate is achieved, thereby improving the yield of scattered sucralose, and a step of removing impurities by oxidizing with an oxidizing agent can also be avoided, thereby simplifying a preparation step of sucralose; and by recycling a sixth water phase and a seventh water phase, sucralose is efficiently and stably prepared from the sucralose-6-acetate crystallization mother liquor, and the yield of sucralose is high.
Inventors:
CHEN YONGLE (CN)
CHEN YUHAN (CN)
LIU GUANGLIANG (CN)
LI PENGFEI (CN)
CHEN YUHAN (CN)
LIU GUANGLIANG (CN)
LI PENGFEI (CN)
Application Number:
PCT/CN2022/126056
Publication Date:
April 25, 2024
Filing Date:
October 19, 2022
Export Citation:
Assignee:
ANHUI JINHE IND CO LTD (CN)
International Classes:
C07H5/02; C07H1/00
Domestic Patent References:
| WO2022056840A1 | 2022-03-24 |
Foreign References:
| CN106674293A | 2017-05-17 | |||
| CN113717237A | 2021-11-30 | |||
| CN114230620A | 2022-03-25 | |||
| CN110372764A | 2019-10-25 | |||
| US20060276639A1 | 2006-12-07 | |||
| CN109734755A | 2019-05-10 |
Attorney, Agent or Firm:
BEIJING GAOWO LAW FIRM (CN)
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