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Title:
METHOD FOR PREPARING TROXERUTIN ESTER USING WHOLE CELL CATALYSIS
Document Type and Number:
WIPO Patent Application WO/2018/218903
Kind Code:
A1
Abstract:
A method for preparing troxerutin ester using whole cell catalysis, which falls within the fields of biological catalysis and pharmaceutical chemistry. The method specifically comprises the following steps: evenly mixing troxerutin and a mixed organic solvent containing pyridine, then adding an acyl donor and a whole cell catalyst, and performing oscillating reaction at a reaction temperature of 25-55 °C; and after the reaction has been finished, separating and purifying the product by means of column chromatography or thin-layer chromatography, so as to obtain the troxerutin ester. The method has the advantages of mild reaction conditions, being environmentally friendly, having simple process, fewer side reactions, and high selectivity.

Inventors:
LI XIAOFENG (CN)
XIN XUAN (CN)
ZHAO GUANGLEI (CN)
Application Number:
PCT/CN2017/113808
Publication Date:
December 06, 2018
Filing Date:
November 30, 2017
Export Citation:
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Assignee:
UNIV SOUTH CHINA TECH (CN)
International Classes:
C12P17/06; C12P7/62
Foreign References:
CN107164423A2017-09-15
CN105063137A2015-11-18
CN105002238A2015-10-28
CN104726375A2015-06-24
CN102718818A2012-10-10
US20070184098A12007-08-09
CN101704866A2010-05-12
Other References:
XIN, X. ET AL.: "Facile and Efficient Acylation of Bioflavonoids Using Whole- Cell Biocatalysts in Organic Solvents", ACS SUSTAINABLE CHEMISTRY & ENGINEERING, vol. 5, no. 11, 11 October 2017 (2017-10-11), pages 10662 - 10672, XP055551243
LAI, XUENENG: "Whole Cell Mediated Acylation of Esculin And Naringin", CHINESE MASTER'S THESES FULL-TEXT DATABASE, 15 December 2015 (2015-12-15)
XIAO, YONGMEI ET AL.: "Enzymatic Synthesis of Vinyl Troxerutin Esters in Nonaqueous Medium", CHINESE JOURNAL OF ORGANIC CHEMISTRY, vol. 30, no. 4, 30 April 2010 (2010-04-30), pages 551 - 557, XP055551269
XIAO, Y. M. ET AL.: "Regioselective enzymatic acylation of troxerutin in nonaqueous medium", CHINESE CHEMICAL LETTERS, vol. 21, 31 December 2010 (2010-12-31), pages 59 - 62, XP055551274
Attorney, Agent or Firm:
YOGO PATENT & TRADEMARK AGENCY LIMITED COMPANY (CN)
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