METHOD FOR PREPARING Y-BRANCHED HYDROPHILIC POLYMER CARBOXYLIC ACID DERIVATIVE

Title:

METHOD FOR PREPARING Y-BRANCHED HYDROPHILIC POLYMER CARBOXYLIC ACID DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2018/177055

Kind Code:

A1

Abstract:

Disclosed in the present invention is a method for preparing a Y-branched hydrophilic polymer carboxylic acid derivative, in particular a method for preparing a Y-branched polyethylene glycol carboxylic acid derivative having a high purity and high molecular weight. The preparation steps are simple, the product after reaction is easy to be separated, the cost for separation is low, the purity and yield of the product are high, facilitating the subsequent preparation of other derivatives and medicament conjugates based on the preparation of the carboxylic acid derivative, being advantageous for industrial amplification and commercial applications. The prepared Y-branched hydrophilic polymer carboxylic acid derivative (in particular the Y-branched polyethylene glycol carboxylic acid derivative having a high molecular weight) product has a high purity and high commercial application value, in particular has use in the preparation of medicaments for preventing and/or treating diseases.

Inventors:

CHEN XIAOMENG (CN)
LIN MEINA (CN)
ZHANG RUJUN (CN)
ZHAO XUAN (CN)

Application Number:

PCT/CN2018/077229

Publication Date:

October 04, 2018

Filing Date:

February 26, 2018

Export Citation:

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Assignee:

JENKEM TECH CO LTD BEIJING (CN)

International Classes:

C08G69/00; A61K31/00; A61K47/00; C08G69/48

Foreign References:

CN1556828A	2004-12-22
CN101029131A	2007-09-05
CN1706865A	2005-12-14
CN101259284A	2008-09-10
CA2304976A1	1999-05-14
CN104530415A	2015-04-22
CN1243779C	2006-03-01

Other References: