METHOD FOR PREPARING 6−AMINOMETHYL−6,11−DIHYDRO−5H−DIBENZ[B,E]AZEPINE

Title:

METHOD FOR PREPARING 6−AMINOMETHYL−6,11−DIHYDRO−5H−DIBENZ[B,E]AZEPINE

Document Type and Number:

WIPO Patent Application WO/2003/084932

Kind Code:

A1

Abstract:

A method for preparing 6−aminomethyl−6,11−dihydro−5H−dibenz[b,e]azepine, characterized in that it comprises reducing 2−(11H−dibenz[b,e]azepine−6−ylmethyl)−1H−isoindole−1,3(2H)−dione with a metal hydride or a metal hydrogen complex compound in an aqueous alcohol solvent, to form N−[(6,11−dihydro−5H−dibenz[b,e]azepine−6−yl)methyl]−o−hydroxymethylbenzamide&semi and N−[(6,11−dihydro−5H−dibenz[b,e]azepine−6−yl)methyl]−o−hydroxymethylbenzamide useful for the preparation.

Inventors:

IKEDA SHIN (JP)
TAKAHASHI YASUHIRO (JP)

Application Number:

PCT/JP2002/003602

Publication Date:

October 16, 2003

Filing Date:

April 11, 2002

Export Citation:

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Assignee:

KONICA CHEMICAL CORP (JP)
IKEDA SHIN (JP)
TAKAHASHI YASUHIRO (JP)

International Classes:

A61K31/55; C07D223/18; C07D223/20; C07D403/06; (IPC1-7): C07D223/20; C07D403/06

Foreign References:

US5312916A	1994-05-17
JP2001131177A	2001-05-15
JP2002193939A	2002-07-10
JP2002193940A	2002-07-10

Other References: