Title:
METHOD FOR PREVENTING AND TREATING LIVER FIBROSIS
Document Type and Number:
WIPO Patent Application WO/2018/107696
Kind Code:
A1
Abstract:
A method for preventing and treating liver fibrosis, comprising administering an effective amount of plasminogen to a subject.
Inventors:
LI JINAN (CN)
Application Number:
PCT/CN2017/089056
Publication Date:
June 21, 2018
Filing Date:
June 19, 2017
Export Citation:
Assignee:
TALENGEN INST LIFE SCIENCES CO LTD (CN)
International Classes:
A61K38/48; A61P1/16
Domestic Patent References:
| WO1997004801A1 | 1997-02-13 |
Foreign References:
| CN101628113A | 2010-01-20 | |||
| CN103384722A | 2013-11-06 | |||
| CN102482338A | 2012-05-30 | |||
| CN102154253A | 2011-08-17 | |||
| US3773919A | 1973-11-20 | |||
| EP0058481A1 | 1982-08-25 |
Other References:
BEIER, J.I.: "Alcoholic liver disease and the potential role of plasmino- gen activator inhibitor-1 and fibrin metabolism", EXPERIMENTAL BIOLOGY AND MEDICINE, vol. 237, no. 1, 31 January 2012 (2012-01-31), pages 1 - 9, XP055510382
ZHU YINGXI: "The Role of the Plasminogen Actibitor-1 in the Pathogenesis of Hepatic Fibrosis, Medicine & Public Health", CHINESE SELECTED DOCTORAL DISSERTATIONS AND MASTER´S THESES FULL-TEXT DATABASES, no. 4, 15 April 2017 (2017-04-15), pages 1 - 75, XP009515576
GHOSH, A. K.: "PAI-1 in Tissue Fibrosis", JOURNAL OF CELLULAR PHYSIOLOGY, vol. 227, no. 2, 1 February 2013 (2013-02-01), pages 493 - 507, XP055493194
BARANYSOLID-PHASE PEPTIDE SYNTHESIS, THE PEPTIDES: ANALYSIS, SYNTHESIS, BIOLOGY. VOL. 2: SPECIAL METHODS IN PEPTIDE SYNTHESIS, vol. 2, pages 3 - 284
MERRIFIELD ET AL., J. AM. CHEM. SOC., vol. 85, 1963, pages 2149 - 2156
STEWART ET AL.: "Solid Phase Peptide Synthesis", 1984, PIERCE CHEM. CO.
GANESAN A., MINI REV. MED CHEM., vol. 6, 2006, pages 3 - 10
CAMARERO JA ET AL., PROTEIN PEPT LETT., vol. 12, 2005, pages 723 - 8
WINNACKER: "From Genes to Clones", 1987, VCH PUBLISHERS
QUEEN ET AL., IMMUNOL. REV., vol. 89, 1986, pages 49
CO ET AL., J. IMMUNOL., vol. 148, 1992, pages 1149
RAUM, D.MARCUS, D.ALPER, C.A.LEVEY, R.TAYLOR, P.D.STARZL, T.E.: "Synthesis of human plasminogen by the liver", SCIENCE, vol. 208, 1980, pages 1036 - 1037
LANGER ET AL., J. BIOMED. MATER. RES., vol. 15, 1981, pages 167 - 277
LANGER, CHEM. TECH., vol. 12, 1982, pages 98 - 105
SIDMAN ET AL., BIOPOLYMERS, vol. 22, 1983, pages 547
DENTON CPBLACK CMABRAHAM DJ: "Mechanisms and consequences of fibosis in systemic sclerosis[J", NAT CLIN PRACT RHEUMATOL, vol. 2, no. 3, 2006, pages 134 - 144
WILSON MSWYNN TA: "Pulmonary fibrosis: pathogenesis, etiology and regulation [J", MUCOSAL IMMUNOL, vol. 2, no. 2, 2009, pages 103 - 121
LIU Y: "Renal fibrosis: new insights into the pathogenesis and therapeutics[J", KIDNEY INT, vol. 69, 2006, pages 213 - 217, XP009137666, DOI: doi:10.1038/sj.ki.5000054
ALEXANDER, C.M.WERB, Z.: "Proteinases and extracellular matrix remodeling", CURR. OPIN. CELL BIOL., vol. 1, 1989, pages 974 - 982, XP000872201, DOI: doi:10.1016/0955-0674(89)90068-9
ALEXANDER CMWERB, Z.: "Cell Biology of Extracellular Matrix", 1991, PLENUM PRESS, article "Extracellular matrix degradation", pages: 255 - 302
WERB, Z.MAINARDI, C.L.VATER, C.A.HARRIS, E.D., JR.: "Endogenous activiation of latent collagenase by rheumatoid synovial cells. Evidence for a role of plasminogen activator", N. ENGL. J. MED., vol. 296, 1977, pages 1017 - 1023
HE, C.S.WILHELM, S.M.PENTLAND, A.P.MARMER, B.L.GRANT, G.A.EISEN, A.Z.GOLDBERG, G.I.: "Tissue cooperation in a proteolytic cascade activating human interstitial collagenase", PROC. NATL. ACAD. SCI. U. S. A, vol. 86, 1989, pages 2632 - 2636
STOPPELLI, M.P.CORTI, A.SOFFIENTINI, A.CASSANI, GBLASI, F.ASSOIAN, R.K.: "Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes", PROC. NATL. ACAD. SCI. U. S. A, vol. 82, 1985, pages 4939 - 4943
VASSALLI, J.D.BACCINO, D.BELIN, D.: "A cellular binding site for the Mr 55, 000 form of the human plasminogen activator, urokinase", J. CELL BIOL., vol. 100, 1985, pages 86 - 92, XP001176730, DOI: doi:10.1083/jcb.100.1.86
WIMAN, B.WALLEN, P.: "Structural relationship between ''glutamic acid'' and ''lysine'' forms of human plasminogen and their interaction with the NH2-terminal activation peptide as studied by affinity chromatography", EUR. J. BIOCHEM., vol. 50, 1975, pages 489 - 494
SAKSELA, O.RIFKIN, D.B.: "Cell-associated plasminogen activation: regulation and physiological functions", ANNU. REV. CELL BIOL., vol. 4, 1988, pages 93 - 126
WALLEN P: "Fibrinolysis", 1980, CRC, article "Biochemistry of plasminogen"
SOTTRUP-JENSEN, L.ZAJDEL, M.CLAEYS, H.PETERSEN, T.E.MAGNUSSON, S.: "Amino-acid sequence of activation cleavage site in plasminogen: homology with ''pro'' part of prothrombin", PROC. NATL. ACAD. SCI. U. S. A, vol. 72, 1975, pages 2577 - 2581
COLLEN, D.LIJNEN, H.R.: "Basic and clinical aspects of fibrinolysis and thrombolysis", BLOOD, vol. 78, 1991, pages 3114 - 3124
MIGNATTI, P.RIFKIN, D.B.: "Biology and biochemistry of proteinases in tumor invasion", PHYSIOL REV., vol. 73, 1993, pages 161 - 195
COLLEN, D.: "Hematology", 2001, AM. SOC. HEMATOL. EDUC. PROGRAM., article "Ham-Wasserman lecture: role of the plasminogen system in fibrin-homeostasis and tissue remodeling", pages: 1 - 9
RIFKIN, D.B.MOSCATELLI, D.BIZIK, J.QUARTO, N.BLEI, F.DENNIS, P.FLAUMENHAFT, R.MIGNATTI, P.: "Growth factor control of extracellular proteolysis", CELL DIFFER. DEV., vol. 32, 1990, pages 313 - 318, XP024562018, DOI: doi:10.1016/0922-3371(90)90045-X
ANDREASEN, P.A.KJOLLER, L.CHRISTENSEN, L.DUFFY, M.J.: "The urokinase-type plasminogen activator system in cancer metastasis: a review", INT. J. CANCER, vol. 72, 1997, pages 1 - 22, XP002210773, DOI: doi:10.1002/(SICI)1097-0215(19970703)72:1<1::AID-IJC1>3.0.CO;2-Z
RIFKIN, D.B.MAZZIERI, R.MUNGER, J.S.NOGUERA, I.SUNG, J.: "Proteolytic control of growth factor availability", APMIS, vol. 107, 1999, pages 80 - 85
MARDER V JNOVOKHATNY V.: "Direct fibrinolytic agents: biochemical attributes, preclinical foundation and clinical potential [J", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, vol. 8, no. 3, 2010, pages 433 - 444
HUNT J APETTEWAY JR S RSCUDERI P ET AL.: "Simplified recombinant plasmin: production and functional comparison of a novel thrombolytic molecule with plasma-derived plasmin [J", THROMB HAEMOST, vol. 100, no. 3, 2008, pages 413 - 419, XP009113156
SOTTRUP-JENSEN LCLAEYS HZAJDEL M ET AL.: "The primary structure of human plasminogen: Isolation of two lysine-binding fragments and one ''mini''-plasminogen (MW, 38, 000) by elastase-catalyzed-specific limited proteolysis [J", PROGRESS IN CHEMICAL FIBRINOLYSIS AND THROMBOLYSIS, vol. 3, 1978, pages 191 - 209, XP000605185
NAGAI NDEMARSIN EVAN HOEF B ET AL.: "Recombinant human microplasmin: production and potential therapeutic properties [J", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, vol. 1, no. 2, 2003, pages 307 - 313, XP055535850
YOSUKE KANNOEN SHUHIROYUKI KANOH ET AL.: "The Antifibrotic Effect of a2AP Neutralization in Systemic Sclerosis Dermal Fibroblasts and Mouse Models of Systemic Sclerosis", J INVEST DERMATOL., vol. 136, no. 4, April 2016 (2016-04-01), pages 762 - 9
DONNELLY SMZHOU XPHUANG JT ET AL.: "Prevention of early glomerulopathy with tolrestat in the streptozotocin-induced diabetic rat", BIOCHEM CELL BIOL., vol. 74, no. 3, 1996, pages 355 - 62
ASHISH ANEJAW.H. WILSON TANGSAMEER BANSILAL ET AL.: "Diabetic Cardiomyopathy: Insights into Pathogenesis, Diagnostic Challenges, and Therapeutic Options", AM J MED., vol. 121, no. 9, September 2008 (2008-09-01), pages 748 - 57, XP024098498, DOI: doi:10.1016/j.amjmed.2008.03.046
SAMUELCSLHEWITSONTDZHANGY ET AL.: "Relaxin ameliorates fibrosis in experimental diabetc cardiomyopathy", ENDOCRINOLOGY, vol. 149, no. 7, July 2008 (2008-07-01), pages 3286 - 93
YUTAKA NAKASHIMAANDREW S. PLUMPELAINE W. RAINES ET AL., ARTERIOSCLER THROMB., vol. 14, no. 1, January 1994 (1994-01-01), pages 133 - 40
YVONNE NITSCHKEGABRIELE WEISSEN-PLENZROBERT TERKELTAUB ET AL.: "Nppl promotes atherosclerosis in ApoE knockout mice", J. CELL. MOL. MED., vol. 15, no. 11, 2011, pages 2273 - 2283, XP055400747, DOI: doi:10.1111/j.1582-4934.2011.01327.x
DOMINIKA NACKIEWICZPAROMITA DEYBARBARA SZCZERBA ET AL.: "Inhibitor of differentiation 3, a transcription factor regulates hyperlipidemia associated kidney disease", NEPHRON EXP NEPHROL., vol. 126, no. 3, 2014, pages 141 - 147
MING GULYU ZHANG.SHENGJIE FAN ET AL.: "Extracts of Rhizoma Polygonati Odorati Prevent High-Fat Diet-Induced Metabolic Disorders in C57BL/6 Mice", PLOS ONE, vol. 8, no. 11, pages e8l724
CRISTHIANE FAVERO AGUIARCRISTIANE NAFFAH-DE-SOUZAANGELA CASTOLDI ET AL.: "Administration of a-Galactosylceramide Improves Adenine-Induced Renal Injury", MOL MED., vol. 21, 18 June 2015 (2015-06-18), pages 553 - 62
MARK A. BARNESMEGAN R. MCMULLENSANJOY ROYCHOWDHURY ET AL.: "Macrophage migration inhibitory factor is required for recruitment of scar-associated macrophages during liver fibrosis", J LEUKOC BIOL., vol. 97, no. l, January 2015 (2015-01-01), pages 161 - 9
TAKAYOSHI YAMAZAFATIMA SAFIRA ALATASRATIH YUNIARTHA ET AL.: "In vivo hepatogenic capacity and therapeutic potential of stem cells from human exfoliated deciduous teeth in liver fibrosis in mice", STEM CELL RES THER., vol. 6, 10 September 2015 (2015-09-10), pages 171
ZHU YINGXI: "The Role of the Plasminogen Actibitor-1 in the Pathogenesis of Hepatic Fibrosis, Medicine & Public Health", CHINESE SELECTED DOCTORAL DISSERTATIONS AND MASTER´S THESES FULL-TEXT DATABASES, no. 4, 15 April 2017 (2017-04-15), pages 1 - 75, XP009515576
GHOSH, A. K.: "PAI-1 in Tissue Fibrosis", JOURNAL OF CELLULAR PHYSIOLOGY, vol. 227, no. 2, 1 February 2013 (2013-02-01), pages 493 - 507, XP055493194
BARANYSOLID-PHASE PEPTIDE SYNTHESIS, THE PEPTIDES: ANALYSIS, SYNTHESIS, BIOLOGY. VOL. 2: SPECIAL METHODS IN PEPTIDE SYNTHESIS, vol. 2, pages 3 - 284
MERRIFIELD ET AL., J. AM. CHEM. SOC., vol. 85, 1963, pages 2149 - 2156
STEWART ET AL.: "Solid Phase Peptide Synthesis", 1984, PIERCE CHEM. CO.
GANESAN A., MINI REV. MED CHEM., vol. 6, 2006, pages 3 - 10
CAMARERO JA ET AL., PROTEIN PEPT LETT., vol. 12, 2005, pages 723 - 8
WINNACKER: "From Genes to Clones", 1987, VCH PUBLISHERS
QUEEN ET AL., IMMUNOL. REV., vol. 89, 1986, pages 49
CO ET AL., J. IMMUNOL., vol. 148, 1992, pages 1149
RAUM, D.MARCUS, D.ALPER, C.A.LEVEY, R.TAYLOR, P.D.STARZL, T.E.: "Synthesis of human plasminogen by the liver", SCIENCE, vol. 208, 1980, pages 1036 - 1037
LANGER ET AL., J. BIOMED. MATER. RES., vol. 15, 1981, pages 167 - 277
LANGER, CHEM. TECH., vol. 12, 1982, pages 98 - 105
SIDMAN ET AL., BIOPOLYMERS, vol. 22, 1983, pages 547
DENTON CPBLACK CMABRAHAM DJ: "Mechanisms and consequences of fibosis in systemic sclerosis[J", NAT CLIN PRACT RHEUMATOL, vol. 2, no. 3, 2006, pages 134 - 144
WILSON MSWYNN TA: "Pulmonary fibrosis: pathogenesis, etiology and regulation [J", MUCOSAL IMMUNOL, vol. 2, no. 2, 2009, pages 103 - 121
LIU Y: "Renal fibrosis: new insights into the pathogenesis and therapeutics[J", KIDNEY INT, vol. 69, 2006, pages 213 - 217, XP009137666, DOI: doi:10.1038/sj.ki.5000054
ALEXANDER, C.M.WERB, Z.: "Proteinases and extracellular matrix remodeling", CURR. OPIN. CELL BIOL., vol. 1, 1989, pages 974 - 982, XP000872201, DOI: doi:10.1016/0955-0674(89)90068-9
ALEXANDER CMWERB, Z.: "Cell Biology of Extracellular Matrix", 1991, PLENUM PRESS, article "Extracellular matrix degradation", pages: 255 - 302
WERB, Z.MAINARDI, C.L.VATER, C.A.HARRIS, E.D., JR.: "Endogenous activiation of latent collagenase by rheumatoid synovial cells. Evidence for a role of plasminogen activator", N. ENGL. J. MED., vol. 296, 1977, pages 1017 - 1023
HE, C.S.WILHELM, S.M.PENTLAND, A.P.MARMER, B.L.GRANT, G.A.EISEN, A.Z.GOLDBERG, G.I.: "Tissue cooperation in a proteolytic cascade activating human interstitial collagenase", PROC. NATL. ACAD. SCI. U. S. A, vol. 86, 1989, pages 2632 - 2636
STOPPELLI, M.P.CORTI, A.SOFFIENTINI, A.CASSANI, GBLASI, F.ASSOIAN, R.K.: "Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes", PROC. NATL. ACAD. SCI. U. S. A, vol. 82, 1985, pages 4939 - 4943
VASSALLI, J.D.BACCINO, D.BELIN, D.: "A cellular binding site for the Mr 55, 000 form of the human plasminogen activator, urokinase", J. CELL BIOL., vol. 100, 1985, pages 86 - 92, XP001176730, DOI: doi:10.1083/jcb.100.1.86
WIMAN, B.WALLEN, P.: "Structural relationship between ''glutamic acid'' and ''lysine'' forms of human plasminogen and their interaction with the NH2-terminal activation peptide as studied by affinity chromatography", EUR. J. BIOCHEM., vol. 50, 1975, pages 489 - 494
SAKSELA, O.RIFKIN, D.B.: "Cell-associated plasminogen activation: regulation and physiological functions", ANNU. REV. CELL BIOL., vol. 4, 1988, pages 93 - 126
WALLEN P: "Fibrinolysis", 1980, CRC, article "Biochemistry of plasminogen"
SOTTRUP-JENSEN, L.ZAJDEL, M.CLAEYS, H.PETERSEN, T.E.MAGNUSSON, S.: "Amino-acid sequence of activation cleavage site in plasminogen: homology with ''pro'' part of prothrombin", PROC. NATL. ACAD. SCI. U. S. A, vol. 72, 1975, pages 2577 - 2581
COLLEN, D.LIJNEN, H.R.: "Basic and clinical aspects of fibrinolysis and thrombolysis", BLOOD, vol. 78, 1991, pages 3114 - 3124
MIGNATTI, P.RIFKIN, D.B.: "Biology and biochemistry of proteinases in tumor invasion", PHYSIOL REV., vol. 73, 1993, pages 161 - 195
COLLEN, D.: "Hematology", 2001, AM. SOC. HEMATOL. EDUC. PROGRAM., article "Ham-Wasserman lecture: role of the plasminogen system in fibrin-homeostasis and tissue remodeling", pages: 1 - 9
RIFKIN, D.B.MOSCATELLI, D.BIZIK, J.QUARTO, N.BLEI, F.DENNIS, P.FLAUMENHAFT, R.MIGNATTI, P.: "Growth factor control of extracellular proteolysis", CELL DIFFER. DEV., vol. 32, 1990, pages 313 - 318, XP024562018, DOI: doi:10.1016/0922-3371(90)90045-X
ANDREASEN, P.A.KJOLLER, L.CHRISTENSEN, L.DUFFY, M.J.: "The urokinase-type plasminogen activator system in cancer metastasis: a review", INT. J. CANCER, vol. 72, 1997, pages 1 - 22, XP002210773, DOI: doi:10.1002/(SICI)1097-0215(19970703)72:1<1::AID-IJC1>3.0.CO;2-Z
RIFKIN, D.B.MAZZIERI, R.MUNGER, J.S.NOGUERA, I.SUNG, J.: "Proteolytic control of growth factor availability", APMIS, vol. 107, 1999, pages 80 - 85
MARDER V JNOVOKHATNY V.: "Direct fibrinolytic agents: biochemical attributes, preclinical foundation and clinical potential [J", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, vol. 8, no. 3, 2010, pages 433 - 444
HUNT J APETTEWAY JR S RSCUDERI P ET AL.: "Simplified recombinant plasmin: production and functional comparison of a novel thrombolytic molecule with plasma-derived plasmin [J", THROMB HAEMOST, vol. 100, no. 3, 2008, pages 413 - 419, XP009113156
SOTTRUP-JENSEN LCLAEYS HZAJDEL M ET AL.: "The primary structure of human plasminogen: Isolation of two lysine-binding fragments and one ''mini''-plasminogen (MW, 38, 000) by elastase-catalyzed-specific limited proteolysis [J", PROGRESS IN CHEMICAL FIBRINOLYSIS AND THROMBOLYSIS, vol. 3, 1978, pages 191 - 209, XP000605185
NAGAI NDEMARSIN EVAN HOEF B ET AL.: "Recombinant human microplasmin: production and potential therapeutic properties [J", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, vol. 1, no. 2, 2003, pages 307 - 313, XP055535850
YOSUKE KANNOEN SHUHIROYUKI KANOH ET AL.: "The Antifibrotic Effect of a2AP Neutralization in Systemic Sclerosis Dermal Fibroblasts and Mouse Models of Systemic Sclerosis", J INVEST DERMATOL., vol. 136, no. 4, April 2016 (2016-04-01), pages 762 - 9
DONNELLY SMZHOU XPHUANG JT ET AL.: "Prevention of early glomerulopathy with tolrestat in the streptozotocin-induced diabetic rat", BIOCHEM CELL BIOL., vol. 74, no. 3, 1996, pages 355 - 62
ASHISH ANEJAW.H. WILSON TANGSAMEER BANSILAL ET AL.: "Diabetic Cardiomyopathy: Insights into Pathogenesis, Diagnostic Challenges, and Therapeutic Options", AM J MED., vol. 121, no. 9, September 2008 (2008-09-01), pages 748 - 57, XP024098498, DOI: doi:10.1016/j.amjmed.2008.03.046
SAMUELCSLHEWITSONTDZHANGY ET AL.: "Relaxin ameliorates fibrosis in experimental diabetc cardiomyopathy", ENDOCRINOLOGY, vol. 149, no. 7, July 2008 (2008-07-01), pages 3286 - 93
YUTAKA NAKASHIMAANDREW S. PLUMPELAINE W. RAINES ET AL., ARTERIOSCLER THROMB., vol. 14, no. 1, January 1994 (1994-01-01), pages 133 - 40
YVONNE NITSCHKEGABRIELE WEISSEN-PLENZROBERT TERKELTAUB ET AL.: "Nppl promotes atherosclerosis in ApoE knockout mice", J. CELL. MOL. MED., vol. 15, no. 11, 2011, pages 2273 - 2283, XP055400747, DOI: doi:10.1111/j.1582-4934.2011.01327.x
DOMINIKA NACKIEWICZPAROMITA DEYBARBARA SZCZERBA ET AL.: "Inhibitor of differentiation 3, a transcription factor regulates hyperlipidemia associated kidney disease", NEPHRON EXP NEPHROL., vol. 126, no. 3, 2014, pages 141 - 147
MING GULYU ZHANG.SHENGJIE FAN ET AL.: "Extracts of Rhizoma Polygonati Odorati Prevent High-Fat Diet-Induced Metabolic Disorders in C57BL/6 Mice", PLOS ONE, vol. 8, no. 11, pages e8l724
CRISTHIANE FAVERO AGUIARCRISTIANE NAFFAH-DE-SOUZAANGELA CASTOLDI ET AL.: "Administration of a-Galactosylceramide Improves Adenine-Induced Renal Injury", MOL MED., vol. 21, 18 June 2015 (2015-06-18), pages 553 - 62
MARK A. BARNESMEGAN R. MCMULLENSANJOY ROYCHOWDHURY ET AL.: "Macrophage migration inhibitory factor is required for recruitment of scar-associated macrophages during liver fibrosis", J LEUKOC BIOL., vol. 97, no. l, January 2015 (2015-01-01), pages 161 - 9
TAKAYOSHI YAMAZAFATIMA SAFIRA ALATASRATIH YUNIARTHA ET AL.: "In vivo hepatogenic capacity and therapeutic potential of stem cells from human exfoliated deciduous teeth in liver fibrosis in mice", STEM CELL RES THER., vol. 6, 10 September 2015 (2015-09-10), pages 171
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BEIJING CAI HE LAW FIRM (CN)
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