Title:
METHOD FOR PRODUCING (1R, 2S)-1-AMINO-2-VINYL CYCLOPROPANE CARBOXYLIC ACID ESTER THAT HAS IMPROVED OPTICAL PURITY
Document Type and Number:
WIPO Patent Application WO/2011/158720
Kind Code:
A1
Abstract:
Disclosed is a method for efficiently producing a (1R, 2S)-1-amino-2-vinyl cyclopropane carboxylic acid ester, which is useful as a pharmaceutical intermediate, at low cost.
Specifically, a (1R, 2S)-1-amino-2-vinyl cyclopropane carboxylic acid ester derivative that has improved optical purity is produced by forming a salt from an optically active carboxylic acid and a 1-amino-2-vinyl cyclopropane carboxylic acid ester in a racemic form or having a low optical purity and then precipitating the salt in a solid form from the solvent.
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Inventors:
TANAKA TATSUYOSHI (JP)
NISHIYAMA AKIRA (JP)
NISHIYAMA AKIRA (JP)
Application Number:
PCT/JP2011/063181
Publication Date:
December 22, 2011
Filing Date:
June 08, 2011
Export Citation:
Assignee:
KANEKA CORP (JP)
TANAKA TATSUYOSHI (JP)
NISHIYAMA AKIRA (JP)
TANAKA TATSUYOSHI (JP)
NISHIYAMA AKIRA (JP)
International Classes:
C07B57/00; C07C227/42; C07C229/48
Domestic Patent References:
| WO2008099730A1 | 2008-08-21 |
Foreign References:
| JP2010510233A | 2010-04-02 |
Other References:
P.L.BEAULIEU ET AL.: "Synthesis of (1R,2S)-1-Amino-2-vinylcyclopropanecarboxylic Acid Vinyl-ACCA) Derivatives:Key Intermediates for the Preparation of Inhibitors of the Hepatitis C Virus NS3 Protease", J.ORG.CHEM., vol. 70, no. 15, 2005, pages 5869 - 5879, XP002686607
Attorney, Agent or Firm:
UEKI, Kyuichi et al. (JP)
Hisakazu Ueki (JP)
Hisakazu Ueki (JP)
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Claims: