Title:
METHOD FOR PRODUCING 2-ACETYL-4H,9H-NAPHTHO[2,3-B]FURAN-4,9-DIONE
Document Type and Number:
WIPO Patent Application WO/2017/013865
Kind Code:
A1
Abstract:
The invention addresses the problem of providing a method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione that is suited to industrial production. The invention provides a method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione by reacting 3-bromo-3-buten-2-one and 2-hydroxy-1,4-naphthoquinone in the presence of a solvent, then obtaining crystals of 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione by adding an alcohol-based solvent and/or water to the reaction system, and treating the crystals by using a specific adsorbent in the presence of a solvent.
Inventors:
YAGI TOSHIKAZU (JP)
SUZUKI SATOSHI (JP)
TATAMIDANI HIROTO (JP)
HASHIMOTO KAZUKI (JP)
SUZUKI SATOSHI (JP)
TATAMIDANI HIROTO (JP)
HASHIMOTO KAZUKI (JP)
Application Number:
PCT/JP2016/003346
Publication Date:
January 26, 2017
Filing Date:
July 15, 2016
Export Citation:
Assignee:
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
International Classes:
C07D307/92; A61K31/343; C07C45/65; C07C49/227
Domestic Patent References:
| WO2014169078A2 | 2014-10-16 | |||
| WO2013166618A1 | 2013-11-14 |
Foreign References:
| JP2013522325A | 2013-06-13 | |||
| JP2014511384A | 2014-05-15 | |||
| JP2010539097A | 2010-12-16 | |||
| JP2015506990A | 2015-03-05 | |||
| JP2010111629A | 2010-05-20 | |||
| JP2008162985A | 2008-07-17 | |||
| JPH11180914A | 1999-07-06 | |||
| JPH04312567A | 1992-11-04 |
Other References:
JIKKEN KAGAKU KOZA (ZOKU) 2 BUNRI TO SEISEI, 25 January 1967 (1967-01-25), pages 159 - 178
YOZAI HANDBOOK, 1 September 1985 (1985-09-01), pages 156 - 158 , 186 to 189, 292 to 294, 350 to 352, 450 to 4
HAGIWARA HISAHIRO ET AL.: "Domino Michael-O- alkylation reaction: one-pot synthesis of 2,4- diacylhydrofuran derivatives and its application to antitumor naphthofuran synthesis", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, vol. 22, 2001, pages 2946 - 2957, XP003016073
HIGGINS CATHERINE A. ET AL.: "Growth inhibitory activity of extracted material and isolated compounds from the fruits of Kigelia pinnata", PLANTA MEDICA, vol. 76, no. 16, 2010, pages 1840 - 1846
YOZAI HANDBOOK, 1 September 1985 (1985-09-01), pages 156 - 158 , 186 to 189, 292 to 294, 350 to 352, 450 to 4
HAGIWARA HISAHIRO ET AL.: "Domino Michael-O- alkylation reaction: one-pot synthesis of 2,4- diacylhydrofuran derivatives and its application to antitumor naphthofuran synthesis", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, vol. 22, 2001, pages 2946 - 2957, XP003016073
HIGGINS CATHERINE A. ET AL.: "Growth inhibitory activity of extracted material and isolated compounds from the fruits of Kigelia pinnata", PLANTA MEDICA, vol. 76, no. 16, 2010, pages 1840 - 1846
Attorney, Agent or Firm:
YAMAMOTO, Shusaku et al. (JP)
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