Title:
METHOD FOR PRODUCING 2'-DEOXY-2'-FLUOROPYRIMIDINE NUCLEOSIDES
Document Type and Number:
WIPO Patent Application WO/2005/040185
Kind Code:
A1
Abstract:
A method for producing a compound represented by the general formula (2) below is characterized in that a compound represented by the general formula (3) below is added when the compound represented by the general formula (1) below is reacted with a hydrogen fluoride in an organic solvent for producing the compound represented by the general formula (2) below.
Inventors:
FUKUMURA KOUKI (JP)
HAYASHI HIDETOSHI (JP)
UMETANI HIDEKI (JP)
HAYASHI HIDETOSHI (JP)
UMETANI HIDEKI (JP)
Application Number:
PCT/JP2004/015783
Publication Date:
May 06, 2005
Filing Date:
October 25, 2004
Export Citation:
Assignee:
MITSUI CHEMICALS INC (JP)
FUKUMURA KOUKI (JP)
HAYASHI HIDETOSHI (JP)
UMETANI HIDEKI (JP)
FUKUMURA KOUKI (JP)
HAYASHI HIDETOSHI (JP)
UMETANI HIDEKI (JP)
International Classes:
C07H19/06; (IPC1-7): C07H19/06
Foreign References:
| JPH10512894A | 1998-12-08 |
Other References:
CODINGTON J.F. ET AL.: "Nucleosides. XVIII. Synthesis of 2'-fluorothymidine, 2'-fluorodeoxyuridine, and other 2'-halogeno-2'-deoxy nucleosides", JOURNAL OF ORGANIC CHEMISTRY, vol. 29, 1964, pages 558 - 564, XP002175523, DOI: doi:10.1021/jo01026a009
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