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Title:
METHOD FOR PRODUCING 2-PYRIDONE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2015/174377
Kind Code:
A1
Abstract:
The objective of the present invention is to provide a method for producing a compound represented by formula (1) or the like, said compound being a 2-pyridone compound that is useful as a pharmaceutical product or a pharmaceutical intermediate, with high yield. A method for producing a 2-pyridone compound represented by formula (1), which is characterized by reacting a 6-benzoyl-2-pyridone compound represented by formula (3) with a sulfone compound represented by formula (4).

Inventors:
YOSHINO, Hironobu (Ltd. Chemical Research Laboratories 10-1, Tsuboi-Nishi 2-chome, Funabashi-sh, Chiba 07, 〒2748507, JP)
UMEDA, Yasuhiro (Ltd. Chemical Research Laboratories 10-1, Tsuboi-Nishi 2-chome, Funabashi-sh, Chiba 07, 〒2748507, JP)
TAKEOKA, Jun (Ltd. Chemical Research Laboratories 10-1, Tsuboi-Nishi 2-chome, Funabashi-sh, Chiba 07, 〒2748507, JP)
NAGAYA, Akihiro (Ltd. Chemical Research Laboratories 10-1, Tsuboi-Nishi 2-chome, Funabashi-sh, Chiba 07, 〒2748507, JP)
SUGAWARA, Yudai (Ltd. Chemical Research Laboratories 10-1, Tsuboi-Nishi 2-chome, Funabashi-sh, Chiba 07, 〒2748507, JP)
YOSHINO, Madoka (Ltd. Chemical Research Laboratories 10-1, Tsuboi-Nishi 2-chome, Funabashi-sh, Chiba 07, 〒2748507, JP)
Application Number:
JP2015/063509
Publication Date:
November 19, 2015
Filing Date:
May 11, 2015
Export Citation:
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Assignee:
NISSAN CHEMICAL INDUSTRIES, LTD. (7-1 Kanda-Nishiki-cho 3-chome, Chiyoda-ku Tokyo, 54, 〒1010054, JP)
TAISHO PHARMACEUTICAL CO., LTD. (24-1, Takada 3-chome Toshima-k, Tokyo 33, 〒1708633, JP)
International Classes:
C07D401/06; C07B53/00; C07B57/00; C07D213/50; C07D213/64; C07D213/84; C07D213/89
Domestic Patent References:
WO2011068211A12011-06-09
WO2014077235A12014-05-22
Foreign References:
JP2013010750A2013-01-17
Other References:
PAUL R. BLAKEMORE: "The modified Julia olefination: alkene synthesis via the condensation of metallated heteroarylalkylsulfones with carbonyl compounds", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS, vol. 1, 2002, pages 2563 - 2585, XP008157314
JEAN B. BAUDIN ET AL.: "A direct synthesis of olefins by reaction of carbonyl compounds with lithio derivatives of 2-[alkyl- or (2'- alkenyl)- or benzyl-sulufonyl]-benzothiazoles", TETRAHEDRON LETTERS, vol. 32, no. 9, 1991, pages 1175 - 1178, XP026648765
See also references of EP 3144305A4
Attorney, Agent or Firm:
SENMYO, Kenji et al. (4th Floor, SIA Kanda Square 17, Kanda-konyacho, Chiyoda-k, Tokyo 35, 〒1010035, JP)
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