Title:
METHOD FOR PRODUCING 3-ACETYLAMINO-4-HYDROXYBENZOIC ACID
Document Type and Number:
WIPO Patent Application WO/2013/179711
Kind Code:
A1
Abstract:
The present invention provides a method for producing a 3-acetylamino-4-hydroxybenzoic acid compound, which is a stable compound, in a simple manner and with high efficiency employing a process using a microorganism. Specifically, the present invention provides: a microorganism having an ability of producing 3-amino-4-hydroxybenzoic acid, said microorganism being so modified as to have an increased activity of producing 3-amino-4-hydroxybenzoic acid from dihydroxyacetone phosphate and aspartate semialdehyde and is also so modified as to have an increased N-hydroxyarylamine O-acetyltransferase (NhoA) activity; a method for producing a 3-acetylamino-4-hydroxybenzoic acid compound using the microorganism; and others.
Inventors:
SHOZUI FUMI (JP)
TAJIMA YOSHINORI (JP)
YOKOYAMA KEIICHI (JP)
TAJIMA YOSHINORI (JP)
YOKOYAMA KEIICHI (JP)
Application Number:
PCT/JP2013/056025
Publication Date:
December 05, 2013
Filing Date:
March 05, 2013
Export Citation:
Assignee:
AJINOMOTO KK (JP)
International Classes:
C12N15/09; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P13/00
Domestic Patent References:
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| WO2010005099A1 | 2010-01-14 | |||
| WO1994025605A1 | 1994-11-10 | |||
| WO2000063388A1 | 2000-10-26 | |||
| WO2001049854A2 | 2001-07-12 | |||
| WO1991001304A1 | 1991-02-07 |
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| JP2004283163A | 2004-10-14 | |||
| JP2008029325A | 2008-02-14 | |||
| JP2004283163A | 2004-10-14 | |||
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Other References:
SUZUKI HIROKAZU ET AL.: "Novel Benzene Ring Biosynthesis from C3 and C4 Primary Metabolites by Two Enzymes", J. BIOL. CHEM., vol. 281, no. 48, 2006, pages 36944 - 36951, XP008146388
YAMAMURA EI-TORA ET AL.: "Purification and biochemical properties of an N-hydroxyarylamine 0-acetyltransferase from Escherichia coli", BIOCHIM. BIOPHYS. ACTA, vol. 1475, 2000, pages 10 - 16, XP004276585
See also references of EP 2857510A4
J. BIOL. CHEM., vol. 281, 2006, pages 36944 - 36951
J. BACTERIOL., vol. 189, 2007, pages 2155 - 2159
BIOCHIM. BIOPHYS. ACTA, vol. 1475, 2000, pages 10 - 16
J. ANTIBIOT., vol. 59, 2006, pages 464
BIOCHIM. BIOPHYS. ACTA., vol. 1475, 2000, pages 10 - 16
"Escherichia coli and Salmonella: Cellular and Molecular Biology", 1996, AMERICAN SOCIETY FOR MICROBIOLOGY PRESS, pages: 2477 - 2483
INT. J. SYST. BACTERIOL., vol. 43, 1993, pages 162 - 173
INT. J. SYST. BACTERIOL., vol. 41, 1991, pages 255
KARLIN; ALTSCHUL, PRO. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873
PEARSON, METHODS ENZYMOL., vol. 183, 1990, pages 63
JOURNAL OF BIOCHEMISTRY, vol. 281, no. 48, pages 36944 - 36951
CADWELL, R. C., PCR METH. APPL, vol. 2, 1992, pages 28
STEMMER, W. P., NATURE, vol. 370, 1994, pages 389
ZHAO, H., NATURE BIOTECHNOL., vol. 16, 1998, pages 258
SUZUKI ET AL., J. BIO. CHEM., vol. 281, 2006, pages 823 - 833
KIKUCHI ET AL., FEMS MICROBIOLOGY LETTERS, vol. 173, 1999, pages 211 - 215
FALCO ET AL., BIOTECHNOLOGY, vol. 13, 1995, pages 577 - 582
GENE, vol. 39, 1985, pages 281 - 286
BIO/TECHNOLOGY, vol. 7, 1989, pages 1067 - 1070
KRICHELDORF, MAKROMOL. CHEM., vol. 193, 1992, pages 2467 - 2476
MARCOS-FERNANDEZ, POLYMER, vol. 42, 2001, pages 7933 - 7941
SUZUKI, J. BACTERIOL., vol. 189, 2007, pages 2155 - 2159
KESELER ET AL., NUCLEIC ACIDS RES., vol. 33, 2005, pages 334 - 337
DEBOER ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 80, 1983, pages 21 - 25
WU ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 75, 1978, pages 5442 - 5446
SUZUKI, J. BIOL. CHEM., vol. 281, 2006, pages 36944 - 36951
NOGUCHI, NAT. CHEM. BIOL., vol. 6, 2010, pages 641 - 643
PEYRET ET AL., MOL. MICROBIOL., vol. 9, 1993, pages 97 - 109
YAMAMURA EI-TORA ET AL.: "Purification and biochemical properties of an N-hydroxyarylamine 0-acetyltransferase from Escherichia coli", BIOCHIM. BIOPHYS. ACTA, vol. 1475, 2000, pages 10 - 16, XP004276585
See also references of EP 2857510A4
J. BIOL. CHEM., vol. 281, 2006, pages 36944 - 36951
J. BACTERIOL., vol. 189, 2007, pages 2155 - 2159
BIOCHIM. BIOPHYS. ACTA, vol. 1475, 2000, pages 10 - 16
J. ANTIBIOT., vol. 59, 2006, pages 464
BIOCHIM. BIOPHYS. ACTA., vol. 1475, 2000, pages 10 - 16
"Escherichia coli and Salmonella: Cellular and Molecular Biology", 1996, AMERICAN SOCIETY FOR MICROBIOLOGY PRESS, pages: 2477 - 2483
INT. J. SYST. BACTERIOL., vol. 43, 1993, pages 162 - 173
INT. J. SYST. BACTERIOL., vol. 41, 1991, pages 255
KARLIN; ALTSCHUL, PRO. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873
PEARSON, METHODS ENZYMOL., vol. 183, 1990, pages 63
JOURNAL OF BIOCHEMISTRY, vol. 281, no. 48, pages 36944 - 36951
CADWELL, R. C., PCR METH. APPL, vol. 2, 1992, pages 28
STEMMER, W. P., NATURE, vol. 370, 1994, pages 389
ZHAO, H., NATURE BIOTECHNOL., vol. 16, 1998, pages 258
SUZUKI ET AL., J. BIO. CHEM., vol. 281, 2006, pages 823 - 833
KIKUCHI ET AL., FEMS MICROBIOLOGY LETTERS, vol. 173, 1999, pages 211 - 215
FALCO ET AL., BIOTECHNOLOGY, vol. 13, 1995, pages 577 - 582
GENE, vol. 39, 1985, pages 281 - 286
BIO/TECHNOLOGY, vol. 7, 1989, pages 1067 - 1070
KRICHELDORF, MAKROMOL. CHEM., vol. 193, 1992, pages 2467 - 2476
MARCOS-FERNANDEZ, POLYMER, vol. 42, 2001, pages 7933 - 7941
SUZUKI, J. BACTERIOL., vol. 189, 2007, pages 2155 - 2159
KESELER ET AL., NUCLEIC ACIDS RES., vol. 33, 2005, pages 334 - 337
DEBOER ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 80, 1983, pages 21 - 25
WU ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 75, 1978, pages 5442 - 5446
SUZUKI, J. BIOL. CHEM., vol. 281, 2006, pages 36944 - 36951
NOGUCHI, NAT. CHEM. BIOL., vol. 6, 2010, pages 641 - 643
PEYRET ET AL., MOL. MICROBIOL., vol. 9, 1993, pages 97 - 109
Attorney, Agent or Firm:
SAKAI, Hiroaki et al. (JP)
Hiroaki Sakai (JP)
Hiroaki Sakai (JP)
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