METHOD FOR PRODUCING 3-HALOGENATED ALKYL PYRAZOLE DERIVATIVE

Title:

METHOD FOR PRODUCING 3-HALOGENATED ALKYL PYRAZOLE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2016/158716

Kind Code:

A1

Abstract:

The present invention provides a method for producing a 3-halogenated alkyl pyrazole derivative (3) with high yield from a low-cost starting material compound by an industrially practicable reaction operation without requiring an inefficient separation operation, while suppressing the generation of isomers. According to the present invention, a 3-halogenated alkyl pyrazole derivative represented by formula (3) is produced by reacting a compound represented by formula (1) and a compound represented by formula (2) with each other, and then reacting the resulting product with a base or an acid. (In the formulae, R1 represents a C1-6 halogenated alkyl group; each of R2 and R3 independently represents a hydrogen atom, a C1-6 alkyl group, a C6-18 aryl group, a substituted C6-26 aryl group, a C4-12 heteroaryl group or a substituted C4-30 heteroaryl group; X represents -CN, -CONR4R5 or COOR6; and each of R4, R5 and R6 independently represents a C1-6 alkyl group.)

Inventors:

SAWAGUCHI MASANORI (JP)
MATSUMURA YASUSHI (JP)

Application Number:

PCT/JP2016/059544

Publication Date:

October 06, 2016

Filing Date:

March 25, 2016

Export Citation:

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Assignee:

ASAHI GLASS CO LTD (JP)

International Classes:

C07D231/14; C07C241/04; C07C243/28

Domestic Patent References:

WO1992012970A1	1992-08-06
WO2009106619A1	2009-09-03
WO2008152138A2	2008-12-18

Foreign References:

EP2644598A1

2013-10-02

Other References:

EL-SAYED,A.A. ET AL.: "Synthesis of pyrazole derivatives using 1-benzoyl-1-phenylhydrazine", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 46, March 1973 (1973-03-01), pages 947 - 949, XP055315685, ISSN: 0009-2673
RAW,S.A. ET AL.: "A one-pot process for the regioselective synthesis of 1,3,4- trisubstituted-1H-pyrazoles", TETRAHEDRON LETTERS, vol. 50, no. 6, 2009, pages 696 - 699, XP025816789, ISSN: 0040-4039