Title:
METHOD FOR PRODUCING 3-PHENYLPROPIONIC ACID ANALOGUE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2023/145966
Kind Code:
A1
Abstract:
Provided is a method for producing 3-phenylpropionic acid analogue compounds given by formula (I), the production method characteristically comprising a step for culturing a lactic acid bacterium from genus Weissella using a culture medium that contains at least 3 mM of a cinnamic acid analogue compound given by formula (II), wherein the lactic acid bacterium exhibits the following properties (1a) to (3a) when the lactic acid bacterium is inoculated to MRS liquid culture medium containing 3 mM 4-hydroxy-3-methoxycinnamic acid and is cultured for 24 hours at 37°C under anaerobic conditions: (1a) a turbidity of at least 1.0; (2a) a ratio for reduction to 3-(4-hydroxy-3-methoxyphenyl)propionic acid of at least 80%; and (3a) a ratio for decarboxylation to 4-vinylguaiacol of less than 5%. Also provided is a lactic acid bacterium that exhibits these properties. 3-Phenylpropionic acid analogue compounds can be efficiently produced using this method and this lactic acid bacterium.
Inventors:
AWA RIYO (JP)
NISHITANI YOSUKE (JP)
NISHITANI YOSUKE (JP)
Application Number:
PCT/JP2023/003055
Publication Date:
August 03, 2023
Filing Date:
January 31, 2023
Export Citation:
Assignee:
MARUZEN PHARM CO LTD (JP)
International Classes:
C12P7/40; C12N1/20
Foreign References:
| JP2019017381A | 2019-02-07 | |||
| JP2021137010A | 2021-09-16 |
Other References:
FILANNINO PASQUALE, GOBBETTI MARCO, DE ANGELIS MARIA, DI CAGNO RAFFAELLA: "Hydroxycinnamic Acids Used as External Acceptors of Electrons: an Energetic Advantage for Strictly Heterofermentative Lactic Acid Bacteria", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 80, no. 24, 15 December 2014 (2014-12-15), US , pages 7574 - 7582, XP093081062, ISSN: 0099-2240, DOI: 10.1128/AEM.02413-14
GAUR GAUTAM, OH JEE-HWAN, FILANNINO PASQUALE, GOBBETTI MARCO, VAN PIJKEREN JAN-PETER, GÄNZLE MICHAEL G.: "Genetic Determinants of Hydroxycinnamic Acid Metabolism in Heterofermentative Lactobacilli", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 86, no. 5, 18 February 2020 (2020-02-18), US , XP093081065, ISSN: 0099-2240, DOI: 10.1128/AEM.02461-19
GAUR GAUTAM, OH JEE-HWAN, FILANNINO PASQUALE, GOBBETTI MARCO, VAN PIJKEREN JAN-PETER, GÄNZLE MICHAEL G.: "Genetic Determinants of Hydroxycinnamic Acid Metabolism in Heterofermentative Lactobacilli", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 86, no. 5, 18 February 2020 (2020-02-18), US , XP093081065, ISSN: 0099-2240, DOI: 10.1128/AEM.02461-19
Attorney, Agent or Firm:
HAYAKAWA Yuzi et al. (JP)
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