Title:
METHOD FOR PRODUCING 3,4-DISUBSTITUTED PYRROLIDINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2012/057093
Kind Code:
A1
Abstract:
The present invention provides a method for commercially advantageously producing, at low cost, an optically active form of an anti-(3S,4R)-3-alkylcarbamoyl-4-hydroxy pyrrolidine derivative or an enantiomer thereof that is a key intermediate for the production of a high-quality optically active form of (3R,4S)-3-alkylaminomethyl-4-fluoropyrrolidine or an enantiomer thereof that is useful as a production intermediate for a pharmaceutical product. The present invention relates to a method for producing an optically active anti-(3S,4R)-4-hydroxy pyrrolidine-3-carboxylic acid amide derivative or an enantiomer thereof by asymmetric hydrogenation of a 4-oxopyrrolidine-3-carboxylic acid amide derivative represented by general formula (I) using an optically active catalyst. (In formula (I), PG1 represents a protecting group of an amino group; and R1 represents hydrogen, an optionally substituted C1-C6 alkyl group or an optionally substituted C3-C8 cycloalkyl group.)
Inventors:
ARAYA ICHIRO
KIYOTA KOICHI
NAGAO MUNEKI
KIYOTA KOICHI
NAGAO MUNEKI
Application Number:
PCT/JP2011/074463
Publication Date:
May 03, 2012
Filing Date:
October 24, 2011
Export Citation:
Assignee:
KYORIN SEIYAKU KK (JP)
ARAYA ICHIRO
KIYOTA KOICHI
NAGAO MUNEKI
ARAYA ICHIRO
KIYOTA KOICHI
NAGAO MUNEKI
International Classes:
C07D207/24; C07B53/00; C07B61/00; C07C269/06
Domestic Patent References:
| WO2007102567A1 | 2007-09-13 | |||
| WO2003078439A1 | 2003-09-25 | |||
| WO2005026147A1 | 2005-03-24 | |||
| WO2007102567A1 | 2007-09-13 |
Foreign References:
| JP2005239617A | 2005-09-08 | |||
| JP2010238077A | 2010-10-25 |
Other References:
ORGANIC LETTERS, vol. 12, no. 3, 2010, pages 512 - 515
"CATALYTIC ASYMMETRIC SYNTHESIS", 2000, WILEY-VCH, pages: 2 - 6
See also references of EP 2634172A4
"CATALYTIC ASYMMETRIC SYNTHESIS", 2000, WILEY-VCH, pages: 2 - 6
See also references of EP 2634172A4
Attorney, Agent or Firm:
OGURI Shohei et al. (JP)
Shohei Oguri (JP)
Shohei Oguri (JP)
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Claims: