Title:
METHOD FOR PRODUCING 3,5-DI-TERTIARY-BUTYLSALICYLIC ACID
Document Type and Number:
WIPO Patent Application WO/2023/195222
Kind Code:
A1
Abstract:
The method for producing 3,5-di-tertiary-butylsalicylic acid according to one aspect of the present invention comprises: a first step for reacting an alkali metal hydroxide with 2,4-di-tertiary-butylphenol using 4-methyltetrahydropyran as a reaction solvent to produce a salt of the 2,4-di-tertiary-butylphenol (wherein X represents an alkali metal); a second step for injecting carbon dioxide into a container that is heated and has the reaction solvent and the alkali salt of the 2,4-di-tertiary-butylphenol enclosed therein to produce a salt of 3,5-di-tertiary-butylsalicylic acid, subsequent to the first step; and a third step for performing a pH value adjustment process for adjusting the pH value to a value of less than 4 to produce a solid matter containing the 3,5-di-tertiary-butylsalicylic acid, subsequent to the second step.
Inventors:
KAWASAKI RYOICHI (JP)
TOGAWA TAKAMITSU (JP)
TOGAWA TAKAMITSU (JP)
Application Number:
PCT/JP2023/003512
Publication Date:
October 12, 2023
Filing Date:
February 03, 2023
Export Citation:
Assignee:
OSAKA SHINYAKU CO LTD (JP)
International Classes:
C07C51/15; C07C65/05
Foreign References:
| JPS6261949A | 1987-03-18 | |||
| JPS63165341A | 1988-07-08 | |||
| JPH0390047A | 1991-04-16 | |||
| JPH1087562A | 1998-04-07 | |||
| JPH10231271A | 1998-09-02 | |||
| CN104086411A | 2014-10-08 |
Attorney, Agent or Firm:
KOUNO Hiroaki (JP)
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