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Title:
METHOD FOR PRODUCING 6-DEOXY-6-RADIOACTIVE IODO-D-GLUCOSE AND POLYMER COMPOUND USED IN SAID METHOD
Document Type and Number:
WIPO Patent Application WO/2016/084193
Kind Code:
A1
Abstract:
A polymer compound which has a constituent unit derived from a monomer represented by formula (I) and a constituent unit derived from a monomer represented by formula (II) (P2-L2-Y2). A method for producing 6-deoxy-6-radioactive iodo-D-glucose, which is characterized by having this polymer compound react with a radioactive iodine ion and cutting a compound labeled with radioactive iodine from the polymer compound. In the formulae, each of P1 and P2 represents a polymerizable group; each of L1 and L2 represents a single bond or a linking group; R1 represents an alkyl group having 1-8 carbon atoms, an alkoxy group, a haloalkyl group, a cyano group or a halogen atom; k represents an integer of 0-4; each of R2-R5 represents an alkyl group having 1-8 carbon atoms or a substituted or unsubstituted phenyl group; and Y2 represents a residue of a phase-transfer catalyst.

Inventors:
TAKAHASHI TAKASHI (JP)
HATAZAWA JUN (JP)
TANAKA HIROSHI (JP)
NAGASAKI ATSUSHI (JP)
Application Number:
PCT/JP2014/081394
Publication Date:
June 02, 2016
Filing Date:
November 27, 2014
Export Citation:
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Assignee:
TOKYO INST TECH (JP)
UNIV OSAKA (JP)
IWAKI SEIYAKU KK (JP)
International Classes:
C07H5/02; C08F26/02
Domestic Patent References:
WO2007063940A12007-06-07
WO2007066567A12007-06-14
WO2011099480A12011-08-18
Other References:
CHIKA NAKAGAWA ET AL.: "Kobunshigata Zenkutai o Mochiiru SPECT-yo Hoshasei Yoso Hyoshikika Kagobutsu no Goseiho no Kaihatsu", SYMPOSIUM ON ORGANIC SYSTHESIS, JAPAN YOSHISHU, 30 May 2014 (2014-05-30), pages 147 - 150
RYOTA TAKEUCHI ET AL.: "Fukugo Kinosei Kobunshi o Mochiita [18F] PET Probe no Koritsuteki Goseiho no Kaihatsu", 92ND ANNUAL MEETING OF THE CHEMICAL SOCIETY OF JAPAN IN SPRING 2012 NEN KOEN YOKOSHU, vol. IV, 2012, pages 1240
HIROSHI TANAKA ET AL.: "Kobunshi Tanji Shiyaku o Mochiita [18F] PET Probe no Shinki Goseiho no Kaihatsu", 90TH ANNUAL MEETING OF THE CHEMICAL SOCIETY OF JAPAN IN SPRING 2010 NEN KOEN YOKOSHU, vol. IV, 2010, pages 1034
CHIKA NAKAGAWA ET AL.: "Zenkutai o Sokusa ni Yusuru Kobunshi o Mochiita Hokokan Yosoka SPECT Probe Gosei", 94TH ANNUAL MEETING OF THE CHEMICAL SOCIETY OF JAPAN IN SPRING 2014 NEN KOEN YOKOSHU, vol. IV, 12 March 2014 (2014-03-12), pages 1443
Attorney, Agent or Firm:
TANAI Sumio et al. (JP)
Sumio Tanai (JP)
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