Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
METHOD FOR PRODUCING 7H-PYRROLO[2, 3-D]PYRIMIDINE DERIVATIVE AND INTERMEDIATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/006968
Kind Code:
A1
Abstract:
The present invention provides: a method for producing a 7H-pyrrolo[2, 3-d]pyrimidine derivative that is useful as a janus kinase (JAK) inhibitor; an intermediate of the 7H-pyrrolo[2, 3-d]pyrimidine derivative; and a method for producing the intermediate. The present invention provides a method for producing 3-[(3S, 4R)-3-methyl-6-(7H-pyrrolo[2, 3-d]pyrimidin-4-yl)-1, 6-diazaspiro[3. 4]octan-1-yl]- 3-oxopropanenitrile, which uses a salt of an organic acid and (3S, 4R)-3-methyl-1, 6-diazaspiro[3. 4]octan-1-carboxylic acid benzyl.

Inventors:
YAMASAKI TAKAHIRO (JP)
HARA YOSHINORI (JP)
SAKAI TAKAYUKI (JP)
MURAKAMI KENGO (JP)
HARA KATSUYOSHI (JP)
MANTA NAOKI (JP)
Application Number:
PCT/JP2016/070046
Publication Date:
January 12, 2017
Filing Date:
July 06, 2016
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
JAPAN TOBACCO INC (JP)
International Classes:
C07D519/00; C07D205/04; C07D487/10; A61K31/519; A61P43/00; C07B61/00
Domestic Patent References:
WO2011013785A12011-02-03
Other References:
STEPHEN M BERGE ET AL: "Pharmaceutical salts", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 66, no. 1, 1977, pages 1 - 19, XP002675560
NORIAKI HIRAYAMA, YUKI KAGOBUTSU KESSHO SAKUSEI HANDBOOK, 2008, pages 10 - 11 , 57 to 72, 78 to 81, XP009508206
KAWABATA, T. ET AL.: "Stereochemical Diversity in Asymmetric Cyclization via Memory of Chirality", J. AM. CHEM. SOC., vol. 128, no. 48, 2006, pages 15394 - 15395, XP055345498
See also references of EP 3321271A4
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Download PDF: