Title:
METHOD FOR PRODUCING 7H-PYRROLO[2, 3-D]PYRIMIDINE DERIVATIVE AND INTERMEDIATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/006968
Kind Code:
A1
Abstract:
The present invention provides: a method for producing a 7H-pyrrolo[2, 3-d]pyrimidine derivative that is useful as a janus kinase (JAK) inhibitor; an intermediate of the 7H-pyrrolo[2, 3-d]pyrimidine derivative; and a method for producing the intermediate. The present invention provides a method for producing 3-[(3S, 4R)-3-methyl-6-(7H-pyrrolo[2, 3-d]pyrimidin-4-yl)-1, 6-diazaspiro[3. 4]octan-1-yl]- 3-oxopropanenitrile, which uses a salt of an organic acid and (3S, 4R)-3-methyl-1, 6-diazaspiro[3. 4]octan-1-carboxylic acid benzyl.
Inventors:
YAMASAKI TAKAHIRO (JP)
HARA YOSHINORI (JP)
SAKAI TAKAYUKI (JP)
MURAKAMI KENGO (JP)
HARA KATSUYOSHI (JP)
MANTA NAOKI (JP)
HARA YOSHINORI (JP)
SAKAI TAKAYUKI (JP)
MURAKAMI KENGO (JP)
HARA KATSUYOSHI (JP)
MANTA NAOKI (JP)
Application Number:
PCT/JP2016/070046
Publication Date:
January 12, 2017
Filing Date:
July 06, 2016
Export Citation:
Assignee:
JAPAN TOBACCO INC (JP)
International Classes:
C07D519/00; C07D205/04; C07D487/10; A61K31/519; A61P43/00; C07B61/00
Domestic Patent References:
WO2011013785A1 | 2011-02-03 |
Other References:
STEPHEN M BERGE ET AL: "Pharmaceutical salts", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 66, no. 1, 1977, pages 1 - 19, XP002675560
NORIAKI HIRAYAMA, YUKI KAGOBUTSU KESSHO SAKUSEI HANDBOOK, 2008, pages 10 - 11 , 57 to 72, 78 to 81, XP009508206
KAWABATA, T. ET AL.: "Stereochemical Diversity in Asymmetric Cyclization via Memory of Chirality", J. AM. CHEM. SOC., vol. 128, no. 48, 2006, pages 15394 - 15395, XP055345498
See also references of EP 3321271A4
NORIAKI HIRAYAMA, YUKI KAGOBUTSU KESSHO SAKUSEI HANDBOOK, 2008, pages 10 - 11 , 57 to 72, 78 to 81, XP009508206
KAWABATA, T. ET AL.: "Stereochemical Diversity in Asymmetric Cyclization via Memory of Chirality", J. AM. CHEM. SOC., vol. 128, no. 48, 2006, pages 15394 - 15395, XP055345498
See also references of EP 3321271A4
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
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