Title:
METHOD FOR PRODUCING 7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE, AND COCRYSTAL OF SAID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2018/117151
Kind Code:
A1
Abstract:
The present invention relates to: a method for producing a 7H-pyrrolo[2,3-d]pyrimidine derivative which is useful as a Janus kinase (JAK) inhibitor; a cocrystal of the derivative; a method for producing the cocrystal; and a method for purifying the 7H-pyrrolo[2,3-d]pyrimidine derivative using the cocrystal. The present invention provides a method for producing, for example, 3-[(3S,4R)-3-methyl-6—(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile, wherein use is made of a cocrystal of 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile with 3,5-dimethylpyrazole.
Inventors:
SHIMAZAKI TAKAHISA (JP)
Application Number:
PCT/JP2017/045728
Publication Date:
June 28, 2018
Filing Date:
December 20, 2017
Export Citation:
Assignee:
JAPAN TOBACCO INC (JP)
International Classes:
C07D519/00; A61K31/519; A61P43/00; C07D231/12
Domestic Patent References:
| WO2011013785A1 | 2011-02-03 | |||
| WO2011013785A1 | 2011-02-03 |
Other References:
See also references of EP 3560931A4
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
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