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Title:
METHOD FOR PRODUCING 7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AND SYNTHETIC INTERMEDIATE OF SAME
Document Type and Number:
WIPO Patent Application WO/2018/117152
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: a method for producing a 7H-pyrrolo[2,3-d]pyrimidine derivative which is useful as a Janus kinase (JAK) inhibitory agent; an intermediate of the same; and a method for producing the intermediate. Provided is a method for producing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)-1,6-Diazaspiro[3.4]octane-1-yl]-3-oxopropanenitrile using an organic acid of (3S,4R)-1-benzyl-3-methyl-1,6-Diazaspiro[3.4]octane and a salt thereof.

Inventors:
TAKIGUCHI, Hiromu (1-1 Murasaki-cho, Takatsuki-sh, Osaka 25, 〒5691125, JP)
HIGASHI, Akinobu (1-1 Murasaki-cho, Takatsuki-sh, Osaka 25, 〒5691125, JP)
INABA, Takashi (1-1 Murasaki-cho, Takatsuki-sh, Osaka 25, 〒5691125, JP)
WATANABE, Takashi (1-1 Murasaki-cho, Takatsuki-sh, Osaka 25, 〒5691125, JP)
TAKEICHI, Tsubasa (1-1 Murasaki-cho, Takatsuki-sh, Osaka 25, 〒5691125, JP)
PETERSEN, Anders Klarskov (Industriparken 55, Ballerup, 2750, DK)
VEDSOE, Per (Industriparken 55, Ballerup, 2750, DK)
JENSEN, Kim Lebek (Industriparken 55, Ballerup, 2750, DK)
BORNHOLDT, Jan (Industriparken 55, Ballerup, 2750, DK)
EBDRUP, Soren (Industriparken 55, Ballerup, 2750, DK)
Application Number:
JP2017/045729
Publication Date:
June 28, 2018
Filing Date:
December 20, 2017
Export Citation:
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Assignee:
JAPAN TOBACCO INC. (2-1 Toranomon 2-chome, Minato-ku Tokyo, 22, 〒1058422, JP)
LEO PHARMA A/S (Industriparken 55, Ballerup, 2750, DK)
International Classes:
C07D519/00; C07C271/22; C07D307/33; C07D403/06; C07D487/10; C07D491/10
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (AOYAMA & PARTNERS, Umeda Hankyu Bldg. Office Tower 8-1, Kakuda-cho, Kita-ku, Osaka-sh, Osaka 17, 〒5300017, JP)
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