Title:
METHOD FOR PRODUCING AMIDE COMPOUND AND DEVICE FOR PRODUCING AMIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2012/039407
Kind Code:
A1
Abstract:
[Problem] To provide a method for efficiently producing an amide compound without reducing the activity of a microbial catalyst, and to provide a device for producing an amide compound that can be advantageously used in this method. [Solution] The method for producing an amide compound has the step of feeding a nitrile compound and water to a reaction tank containing, as a catalyst, microbial cells and/or a microbial processed product thereof containing nitrile hydratase, the temperature of the liquid in the tank being maintained at 0−50°C, and the ingredients being fed at a temperature 10°C or less above the temperature of the liquid in the reaction tank. The device for producing an amide compound comprises: a reaction tank for producing an amide compound by the hydration of a nitrile compound using, as a catalyst, microbial cells and/or a microbial processed product thereof containing nitrile hydratase; a starting material feed line for feeding the nitrile compound and water to the reaction tank; and a temperature control device provided to the starting material feed line.
Inventors:
ISHIDA TSUTOMU (JP)
SATO ARATA (JP)
WATANABE SHIGEO (JP)
ARII TERUO (JP)
SATO ARATA (JP)
WATANABE SHIGEO (JP)
ARII TERUO (JP)
Application Number:
PCT/JP2011/071424
Publication Date:
March 29, 2012
Filing Date:
September 21, 2011
Export Citation:
Assignee:
MITSUI CHEMICALS INC (JP)
ISHIDA TSUTOMU (JP)
SATO ARATA (JP)
WATANABE SHIGEO (JP)
ARII TERUO (JP)
ISHIDA TSUTOMU (JP)
SATO ARATA (JP)
WATANABE SHIGEO (JP)
ARII TERUO (JP)
International Classes:
C12P13/02; C12M1/00
Domestic Patent References:
| WO2007132601A1 | 2007-11-22 |
Foreign References:
| US6043061A | 2000-03-28 |
Other References:
LEE C.Y. ET AL.: "Continuous production of acrylamide using immobilized Brevibacterium sp. CH2 in a two-stage packed bed reactor", BIOTECHNOLOGY LETTERS, vol. 12, no. 1, 1990, pages 23 - 28, XP002942260, DOI: doi:10.1007/BF01028487
PARK S.H. ET AL.: "Optimization of Operating Temperature for Continuous Glucose Isomerase Reactor System", BIOTECHNOLOGY AND BIOENGINEERING, vol. 23, 1981, pages 1237 - 1254, XP002298042, DOI: doi:10.1002/bit.260230606
PARK S.H. ET AL.: "Optimization of Operating Temperature for Continuous Glucose Isomerase Reactor System", BIOTECHNOLOGY AND BIOENGINEERING, vol. 23, 1981, pages 1237 - 1254, XP002298042, DOI: doi:10.1002/bit.260230606
Attorney, Agent or Firm:
SSINPAT PATENT FIRM (JP)
Patent business corporation SSINPAT (JP)
Patent business corporation SSINPAT (JP)
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Claims: