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Title:
METHOD FOR PRODUCING AMINO ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2016/021711
Kind Code:
A1
Abstract:
 The present invention addresses the problem of providing a method for inexpensively, stably and industrially producing, at high yields, lacosamide having high optical purity. The abovementioned problem is solved by providing a method for inexpensively, stably and industrially producing, at high yields, lacosamide having high optical purity is made possible by implementing, as a key step, amination using benzylamine or a derivative thereof. The abovementioned problem is further solved by providing an intermediate that is useful in the production of lacosamide.

Inventors:
SEKI, Masahiko (13-4 Uchikanda 1-chome, Chiyoda-k, Tokyo 47, 〒1010047, JP)
Application Number:
JP2015/072474
Publication Date:
February 11, 2016
Filing Date:
August 07, 2015
Export Citation:
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Assignee:
API CORPORATION (13-4, Uchikanda 1-chome Chiyoda-k, Tokyo 47, 〒1010047, JP)
International Classes:
C07C231/12; A61K31/16; A61P25/08; A61P29/00; C07C231/02; C07C231/20; C07C231/24; C07C237/06; C07B53/00; C07B57/00; C07B61/00
Domestic Patent References:
WO2014068333A22014-05-08
WO2012069855A12012-05-31
Foreign References:
JP2000509068A2000-07-18
JP2012508162A2012-04-05
JP2013518092A2013-05-20
JPH0570415A1993-03-23
Other References:
MIYAZAKI, H. ET AL.: "Preparations of Optically Active Homocysteine and Homocystine by Asymmetric Transformation of (RS)-1,3-Thiazane- 4-carboxylic Acid", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 66, no. 2, 1993, pages 536 - 540, XP003005639, DOI: doi:10.1246/bcsj.66.536
CLARK, J.C. ET AL.: "A new asymmetric transformation of alpha-amino-acid esters with (+)- tartaric acid", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS, vol. 1, no. Issue 5, 1976, pages 475 - 481, XP009141642
Attorney, Agent or Firm:
TAKASHIMA, Hajime (Meiji Yasuda Seimei Osaka Midosuji Bldg, 1-1 Fushimimachi 4-chome, Chuo-ku, Osaka-sh, Osaka 44, 〒5410044, JP)
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