Title:
METHOD FOR PRODUCING AMINOSTILBENE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2003/000645
Kind Code:
A1
Abstract:
A specific aminostilbene derivative or a salt thereof such as (Z)−3,4,4',5−tetramethoxy−3'−aminostilbene, which is important as an active component of an anticancer drug or an intermediate for the production of the component, can be commercially produced with good efficiency by a method comprising reacting a specific nitrostilbene derivative such as (Z)−3,4,4',5−tetramethoxy−3'−nitrostilbene with formic acid and&sol or a formate salt in the presence of a noble metal catalyst such as a platinum catalyst or a palladium catalyst, to thereby selectively reduce a nitro group alone.
Inventors:
YAMAMOTO TAKASHI (JP)
MATSUEDA HIROYUKI (JP)
NAITO MASAKI (JP)
ARAI ISAO (JP)
YATAGAI MASANOBU (JP)
MATSUEDA HIROYUKI (JP)
NAITO MASAKI (JP)
ARAI ISAO (JP)
YATAGAI MASANOBU (JP)
Application Number:
PCT/JP2002/006174
Publication Date:
January 03, 2003
Filing Date:
June 20, 2002
Export Citation:
Assignee:
AJINOMOTO KK (JP)
YAMAMOTO TAKASHI (JP)
MATSUEDA HIROYUKI (JP)
NAITO MASAKI (JP)
ARAI ISAO (JP)
YATAGAI MASANOBU (JP)
YAMAMOTO TAKASHI (JP)
MATSUEDA HIROYUKI (JP)
NAITO MASAKI (JP)
ARAI ISAO (JP)
YATAGAI MASANOBU (JP)
International Classes:
C07C213/02; C07C217/84; (IPC1-7): C07C217/84; C07C213/02; C07B61/00
Domestic Patent References:
| WO1998039323A1 | 1998-09-11 |
Foreign References:
| EP0641767A1 | 1995-03-08 | |||
| JPH08283216A | 1996-10-29 |
Other References:
PINNEY K.G. ET AL.: "Synthesis and biological evalution of aryl azide derivatives of combretastatin A-4 as molecular probes for tubulin", BIOORG. MED. CHEM., vol. 8, no. 10, 2000, pages 2417 - 2425, XP002955631
CUSHMAN M. ET AL.: "Synthesis and evalution of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization", J. MED. CHEM., vol. 34, 1991, pages 2579 - 2588, XP002955632
OHSUMI K. ET AL.: "Novel combretastatin analogues effective against murine solid tumors: design and structure-activity relationships", J. MED. CHEM., vol. 41, no. 16, 1998, pages 3022 - 3032, XP002102895
GOWDA D.C. ET AL.: "Catalytic transfer hydrogenation of aromatic nitro compounds by employing ammonium formate and 5% platinum on carbon", SYNTHETIC COMMUNICATIONS, vol. 30, no. 20, 2000, pages 3639 - 3644, XP002955633
VARIYAR P.S. ET AL.: "Synthesis of 3,4-dihydroxy-6-(N-ethylamino)banzamide, a new phenolic compound isolated from green pepper (Piper nigrum L.) berries", INDIAN J. CHEM., SECT. B: ORG. CHEM. INCL. MED. CHEM., vol. 34B, no. 10, 1995, pages 911 - 913, XP002955634
CUSHMAN M. ET AL.: "Synthesis and evalution of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization", J. MED. CHEM., vol. 34, 1991, pages 2579 - 2588, XP002955632
OHSUMI K. ET AL.: "Novel combretastatin analogues effective against murine solid tumors: design and structure-activity relationships", J. MED. CHEM., vol. 41, no. 16, 1998, pages 3022 - 3032, XP002102895
GOWDA D.C. ET AL.: "Catalytic transfer hydrogenation of aromatic nitro compounds by employing ammonium formate and 5% platinum on carbon", SYNTHETIC COMMUNICATIONS, vol. 30, no. 20, 2000, pages 3639 - 3644, XP002955633
VARIYAR P.S. ET AL.: "Synthesis of 3,4-dihydroxy-6-(N-ethylamino)banzamide, a new phenolic compound isolated from green pepper (Piper nigrum L.) berries", INDIAN J. CHEM., SECT. B: ORG. CHEM. INCL. MED. CHEM., vol. 34B, no. 10, 1995, pages 911 - 913, XP002955634
Attorney, Agent or Firm:
Ishida, Yasumasa (Bohsei Bldg. 7th Floor, 20-12, Shin-Yokohama
3-chome, Kohoku-k, Yokohama-shi Kanagawa, JP)
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