Title:
METHOD FOR PRODUCING ANTIBODY AGAINST TARGET ANTIGEN
Document Type and Number:
WIPO Patent Application WO/2015/152417
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method or the like with which it is possible to efficiently produce an antibody against a target antigen. The present invention is a method for producing an antibody against a target antigen, said method being characterized by comprising: recovering an antibody against a target antigen from a biological sample derived from a non-human animal after transplanting and engrafting, to the non-human animal, a transformed cell capable of expressing a protein that fuses said antigen and a protein domain capable of inducing an apoptosis signal due to mutual close proximity.
Inventors:
SATOFUKA HIROYUKI (JP)
Application Number:
PCT/JP2015/060678
Publication Date:
October 08, 2015
Filing Date:
March 30, 2015
Export Citation:
Assignee:
ORDER MADE MEDICAL RES INC (JP)
International Classes:
C07K16/28; C12N5/10; C07K19/00; C12N15/02; C12N15/09; C12P21/08
Domestic Patent References:
| WO2012026615A1 | 2012-03-01 | |||
| WO2010098471A1 | 2010-09-02 |
Other References:
TAKEBAYASHI H. ET AL.: "Hormone-induced Apoptosis by Fas-Nuclear Receptor Fusion Proteins: Novel Biological Tools for Controlling Apoptosis in Vivo", CANCER RESEARCH, vol. 56, 1996, pages 4164 - 4170, XP002142783
MASAHIRO KAWAHARA ET AL.: "Development of an antibody/receptor chimera that transduces a cell death signal dependent on an antigen", JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY (DAI 85 KAI ANNUAL MEETING OF THE JAPANESE BIOCHEMICAL SOCIETY PROGRAM GO, vol. 84, no. 11, 22 November 2012 (2012-11-22), pages 3
SIEGEL R. M. ET AL.: "Death-effector Filaments: Novel Cytoplasmic Structures that Recruit Caspases and Trigger Apoptosis", THE JOURNAL OF CELL BIOLOGY, vol. 141, no. 5, 1998, pages 1243 - 1253
SAMEL D. ET AL.: "Generation of a FasL-based Proapoptotic Fusion Protein Devoid of Systemic Toxicity due to Cell -surface Antigen-restricted Activation", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 34, 2003, pages 32077 - 32082, XP002413361, DOI: doi:10.1074/jbc.M304866200
OBEID M. ET AL.: "Calreticulin exposure dictates the immunogenicity of cancer cell death", NATURE MEDICINE, vol. 13, no. 1, 2007, pages 54 - 61, XP002440487, DOI: doi:10.1038/nm1523
MASAHIRO KAWAHARA ET AL.: "Development of an antibody/receptor chimera that transduces a cell death signal dependent on an antigen", JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY (DAI 85 KAI ANNUAL MEETING OF THE JAPANESE BIOCHEMICAL SOCIETY PROGRAM GO, vol. 84, no. 11, 22 November 2012 (2012-11-22), pages 3
SIEGEL R. M. ET AL.: "Death-effector Filaments: Novel Cytoplasmic Structures that Recruit Caspases and Trigger Apoptosis", THE JOURNAL OF CELL BIOLOGY, vol. 141, no. 5, 1998, pages 1243 - 1253
SAMEL D. ET AL.: "Generation of a FasL-based Proapoptotic Fusion Protein Devoid of Systemic Toxicity due to Cell -surface Antigen-restricted Activation", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 34, 2003, pages 32077 - 32082, XP002413361, DOI: doi:10.1074/jbc.M304866200
OBEID M. ET AL.: "Calreticulin exposure dictates the immunogenicity of cancer cell death", NATURE MEDICINE, vol. 13, no. 1, 2007, pages 54 - 61, XP002440487, DOI: doi:10.1038/nm1523
Attorney, Agent or Firm:
KOBAYASHI, Hiroshi et al. (JP)
Kobayashi 浩 (JP)
Kobayashi 浩 (JP)
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